An Overview of Biomedical Applications for Gold Nanoparticles Against Lung Cancer Publisher



Kumari V¹ ; Vishwas S¹ ; Kumar R¹ ; Kakoty V¹ ; Khursheed R¹ ; Babu MR¹ ; Harish V¹ ; Mittal N² ; Singh PK³ ; Alharthi NS⁴ ; Hakami MA⁵ ; Aba Alkhayl FF⁶ ; Gupta G^{7, 8} ; Rubis GD^{9, 10} Show All Authors
Source: Journal of Drug Delivery Science and Technology Published:2023

Abstract

Lung cancer (LC) is the commonest class of cancer worldwide and is the reason for more deaths than any other type. Treatment of LC using conventional therapy has some limitations such as poor bioavailability and non-site release of drug causing various side effects. However, the use of nanotechnology makes it possible to offer efficacious treatment of LC by offering nanometer sized formulation that helps in better penetration of drug inside tumor cells and site specific drug release. Among various nanoparticles, gold nanoparticles (GNPs) has found unique and important application in the biomedical application of nanoparticles in various diseases, especially cancer. Owing to their high biocompatibility and stability against oxidation in vivo, tunable nano size, ease of functionalization with chemotherapeutic agents, capacity to enhance bioavailability and site specificity of entrapped drug, capacity to interact with visible light, make GNPs as special carrier for biomedical application in LC. GNPs can absorb infrared radiation and have optical qualities as well. In the present review, various aspects of LC and theranostic role of GNPs are comprehensively covered. These include prevalence, classification, economic burden, pathophysiology as well as commonly available therapies of LC. This was followed by advantages, synthesis, biomedical application of GNPs in treating LC as well as their fate in the body. Overall, the uniqueness of review relies on the fact that it covers all aspects of LC and all possibilities by which GNPs can offer their best role in management of LC. © 2023 Elsevier B.V.