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Modulation of the Effects of the Cannabinoid Agonist, Acpa, on Spatial and Non-Spatial Novelty Detection in Mice by Dopamine D1 Receptor Drugs Infused Into the Basolateral Amygdala Publisher Pubmed



Mohammadi M1 ; Nasehi M2 ; Zarrindast MR1, 3, 4, 5
Authors

Source: Behavioural Brain Research Published:2015


Abstract

Aim: The amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes. This study investigates the effect of basolateral amygdale (BLA) dopamine receptors on spatial and non-spatial novelty detection deficit, induced by a selective CB1 cannabinoid receptor agonist (Arachidonylcyclopropylamide; ACPA), during a non-associative task. Methods: Male mice weighing 30-35. g were used. Open field procedure was employed to assess the spatial and non-spatial memory retention. Results: Our data showed that post-training intraperitoneal injection of ACPA (0.02. mg/kg), intra-BLA microinjection of SKF38393 (D1 dopamine receptor agonist; at higher dose, 0.1. μg/mouse) and SCH23390 (D1 dopamine receptor antagonist; at lowest dose, 0.005. μg/mouse) impaired both spatial and non-spatial novelty detection. Moreover, intra-BLA microinjection of subthreshold dose of SKF38393 or SCH23390 restored and potentiated the spatial and non-spatial novelty detection impairment caused by ACPA, respectively. Conclusion: Our results suggested that the ACPA induced impairment of memory retention, may occur through BLA D1 dopamine receptors. © 2014 Elsevier B.V.
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