Development of an Analytical Method for Determination of Carboplatin and Oxaliplatin in Resource Water, Prediction and Environmental Risk Assessment



Alimohammadi M^{1, 2} ; Asadighalhari M³ ; Ghafuri Y³
Source: Journal of Environmental Treatment Techniques Published:2020

Abstract

Carboplatin and Oxaliplatin as cytotoxic drugs have developed in recent years as a group of antineoplastic agents, have the ability to kill or stop the growth of certain living cells and are used in chemotherapy of cancer. That their function is through the disruption of cell division. This study aimed to determine carboplatin and Oxaliplatin in wastewater samples by the characterization of the LC-MS/MS method. The method was carried out on ODS C18 (250 mm, 3.5 µm) in which the mobile phase was A = Water +0.1% formic acid, B= methanol +0.1% formic acid, (A / B) = 20:80(V/V), flow rate: 0.3 mL/min, and injection volumes: 5 µL. The method was validated for LOD, LOQ, accuracy and precision. Results of environmental risk assessment showed that RQ (risk quotient) for Carboplatin and Oxaliplatin were 0.51 and 0.038 respectively that indicates all of platinum compounds had low environmental exposure risk . In this regard, studies should be carried out to evaluate the toxicity and genotoxicity effects of the metabolites of cytotoxic platinum compounds and strategies to removal of these compounds. © 2020, Dorma Journals. All rights reserved.