The Impact of Peppermint Oil Aromatherapy on Hemodynamic Parameters, Anxiety, and Stress in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial Publisher



Sharafi H ; Hosseinpour A ; Hosseini Amiri M ; Khahan Yazdi I
Source: Global Advances in Integrative Medicine and Health Published:2026

Abstract

Background: Acute coronary syndrome (ACS) is a critical condition with diverse clinical presentations. Aromatherapy, particularly with peppermint essential oil, has been explored for its potential to alleviate patient symptoms. Objective: This study examines the effects of peppermint essential oil aromatherapy on anxiety, stress, and hemodynamic parameters in patients with ACS. Methods: This randomized, double-blind clinical trial involved ACS patients from Qom University hospitals, recruited between July 2023 and January 2024. The intervention group received 0.2 mL of peppermint essential oil on an eye pad, while the control group received normal saline. Both groups underwent 20-minute sessions in a controlled environment, with data on demographics, stress, anxiety, and hemodynamic parameters collected. Results: Peppermint oil significantly reduced systolic blood pressure (from 139.77 ± 10.83 to 126.36 ± 7.49 mmHg, P < 0.001), diastolic blood pressure, heart rate, pain scores, anxiety (from 24.64 ± 5.15 to 19.55 ± 3.10, P < 0.001), and stress levels (from 25.00 ± 5.14 to 17.18 ± 4.42, P < 0.001) compared to the placebo group. Conclusion: Peppermint essential oil aromatherapy significantly improves cardiac parameters and reduces anxiety and stress in ACS patients. These findings suggest that incorporating aromatherapy into clinical practice may enhance patient well-being and provide a complementary approach to managing the challenges associated with ACS. © The Author(s) 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).