Targeting Wnt Signaling Pathway by Polyphenols: Implication for Aging and Age-Related Diseases Publisher Pubmed



Maleki Dana P¹ ; Sadoughi F¹ ; Mansournia MA² ; Mirzaei H¹ ; Asemi Z¹ ; Yousefi B^{3, 4}
Source: Biogerontology Published:2021

Abstract

Age is an important risk factor for different diseases. The same mechanisms that promote aging are involved in the development and progression of age-associated diseases. Polyphenols are organic compounds found in fruits and vegetables. Due to their beneficial properties (e.g. antioxidant and anti-inflammatory), polyphenols have been extensively used for treating chronic diseases. To exert their functions, polyphenols target various molecular mechanisms and signaling pathways, such as mTOR, NF-κB, and Wnt/β-catenin. Wnt signaling is a critical pathway for developmental processes. Besides, dysregulation of this signaling pathway has been observed in various diseases. Several investigations have been conducted on Wnt inhibitors at pre-clinical stages, showing promising results. Herein, we review the studies dealing with the role of polyphenols in targeting the Wnt signaling pathways in aging processes and age-associated diseases, including cancer, diabetes, Alzheimer’s disease, osteoporosis, and Parkinson’s disease. © 2021, The Author(s), under exclusive licence to Springer Nature B.V.