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Potentiometric Sensor Modified With Molecularly Imprinted Polymer for Determination of Ceftriaxone in Human Serum



Khadem M1 ; Norouzi MA1 ; Heydari D2
Authors

Source: Brazilian Journal of Analytical Chemistry Published:2017

Abstract

In this work, a new potentiometric sensor modified with molecularly imprinted polymer (MIP) was studied for determination of ceftriaxone in serum samples. The MIP was synthesized using the ceftriaxone as a template molecule. After the optimization of the MIP composition, it was applied in the membrane sensor. The optimization of membrane composition was also conducted, leading to its Nernstian response to the ceftriaxone over the concentration range 1×10-1 to 5×10-3 mol L-1 with a detection limit of 5.04×10-4 mol L-1. The PVC membrane sensor showed the optimum response (R2: 0.999, slope: 49.19 mV decade-1) by the composition of MIP: 0.07 g, PVC: 0.08 g, DOP: 0.2 mL, and THF: 2.5 mL. The sensor showed good selectivity and was successfully applied for potentiometric determination of ceftriaxone in human serum samples. © 2017, DKK Comunicacao. All rights reserved.
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