Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Association of Serpind1 Expression With Grade, Stage and Presence of Metastasis in Breast Cancer



Namini NM1 ; Abdollahi A2 ; Movahedi M1 ; Razavi AE3 ; Saghiri R4
Authors

Source: Indian Journal of Biochemistry and Biophysics Published:2021

Abstract

The role of SERPIND1 gene in the development of breast cancer is completely unknown. The aim of the present study was to assess the expression of SERPIND1 in patients suffering from breast malignancies. Tumoural specimens and non-tumoural adjacent tissues were collected from 31 patients who were pathologically confirmed for breast cancer. Furthermore, 43 fasting venous blood samples were collected from the breast cancer patients as well as from the healthy volunteers as control group. The SERPIND1 mRNA expression levels were assessed using the q-RT PCR while the plasma levels of SERPIND1 protein were detected using ELISA. The SERPIND1 relative expression levels were compared with the clinicopathological factors. The expression of the SERPIND1 was significantly higher at both mRNA and protein levels in breast cancer patients compared to the control groups. Moreover, the relative expression of the SERPIND1 showed a significant positive correlation with cancer grade, stage and presence of metastasis (P< 0.05). The findings suggest that the SERPIND1 may be a metastasis-enhancer factor in breast cancer and a strong predictive marker for distinguishing patients with poor prognosis. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.
Related Docs
View other Related Docs
1. Cross-Talk Between Non-Ionizing Electromagnetic Fields and Metastasis; Emt and Hybrid E/M May Explain the Anticancer Role of Emfs, Progress in Biophysics and Molecular Biology (2023)
2. Plasma Mir-21, Mir-155, Mir-10B, and Let-7A As the Potential Biomarkers for the Monitoring of Breast Cancer Patients, Scientific Reports (2018)
3. He4, a New Potential Tumor Marker for Early Diagnosis and Predicting of Breast Cancer Progression, Iranian Journal of Pathology (2021)
Experts (# of related papers)
View all Related Experts
Pantea Izadi (2)
Ramesh Omranipoor (2)
Other Related Docs
4. Association of Pon1, Lep and Lepr Polymorphisms With Susceptibility to Breast Cancer: A Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2021)
5. Fatty Acid Profiles and Delta9 Desaturase (Stearoyl-Coa Desaturase; Scd 1) Expression in Adipose Tissue Surrounding Benign and Malignant Breast Tumors, Heliyon (2023)
6. The Upregulation of Hsa-Mir-181B-1 and Downregulation of Its Target Cyld in the Late-Stage of Tumor Progression of Breast Cancer, Indian Journal of Clinical Biochemistry (2020)
7. Over-Expression of Notch1 As a Biomarker for Invasive Breast Ductal Carcinoma, 3 Biotech (2016)
8. Expression of Mirnas Targeting Mtor and S6k1 Genes of Mtor Signaling Pathway Including Mir-96, Mir-557, and Mir-3182 in Triple-Negative Breast Cancer, Applied Biochemistry and Biotechnology (2018)
9. Gene Expression Profiles of Cyp24a1 and Cyp27b1 in Malignant and Normal Breast Tissues, Molecular Medicine Reports (2017)
10. Evaluation of the Relationship Between Expression of Villin and Gelsolin Genes and Axillary Lymph Node Metastasis in Patients With Breast Cancer, Iranian Journal of Pathology (2021)
11. The Expression Levels of Circulating Mir-129 and Mir-203A in Association With Breast Cancer and Related Metastasis, Iranian Journal of Public Health (2022)
12. Integrative Analyses of Triple Negative Dysregulated Transcripts Compared With Non-Triple Negative Tumors and Their Functional and Molecular Interactions, Journal of Cellular Physiology (2019)
13. A Review of Salivary Biomarkers in Breast Cancer, Current Women's Health Reviews (2023)
14. Evaluation of Arylsulfatase D (Arsd) and Long Noncoding Rna Arsd-As1 Gene Expression in Breast Cancer Patients and Their Association With Oncogenic Transcription Factors, Journal of B.U.ON. (2020)
15. Down-Regulated Microrna-124 Expression As Predictive Biomarker and Its Prognostic Significance With Clinicopathological Features in Breast Cancer Patients, Diagnostic Pathology (2015)
16. Correlation of Ki67 Expression With Hormone Receptors, Human Epidermal Growth Factor Receptor-2 (Her-2) Status, P53 Mutation and Clinicopathological Characteristics in Pathologic Specimens of Breast Cancer Patients, Galen Medical Journal (2016)
17. Akap3 Correlates With Triple Negative Status and Disease Free Survival in Breast Cancer, BMC Cancer (2015)
18. Significance of Egfr Mrna Expression in Luminal and Triple Negative Breast Tumors, International Journal of Cancer Management (2018)
19. Expression Analysis of Long Non-Coding Pcat-1 in Breast Cancer, International Journal of Hematology-Oncology and Stem Cell Research (2017)
20. Identification and Validation of Stage-Associated Pbmc Biomarkers in Breast Cancer Using Ms-Based Proteomics, Frontiers in Oncology (2020)