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Colonic Immune Cells in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis Publisher Pubmed



Bashashati M1 ; Moossavi S2, 3 ; Cremon C4 ; Barbaro MR4 ; Moraveji S1 ; Talmon G5, 6 ; Rezaei N7 ; Hughes PA8 ; Bian ZX9 ; Choi CH10 ; Lee OY11 ; Coeffier M12 ; Chang L13 ; Ohman L14 Show All Authors
Authors
  1. Bashashati M1
  2. Moossavi S2, 3
  3. Cremon C4
  4. Barbaro MR4
  5. Moraveji S1
  6. Talmon G5, 6
  7. Rezaei N7
  8. Hughes PA8
  9. Bian ZX9
  10. Choi CH10
  11. Lee OY11
  12. Coeffier M12
  13. Chang L13
  14. Ohman L14
  15. Schmulson MJ15
  16. Mccallum RW1
  17. Simren M16, 17
  18. Sharkey KA18
  19. Barbara G4

Source: Neurogastroenterology and Motility Published:2018


Abstract

Background & Aims: Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta-analysis of case–control studies that compared immune cell counts in colonic biopsies of IBS patients and controls. Methods: PubMed and Embase were searched in February 2017. Results were pooled using standardized mean difference (SMD) and were considered significant when zero was not within the 95% confidence interval (CI). Heterogeneity was assessed based on I2 statistics where I2 ≤ 50% and I2 > 50% indicated fixed and random effect models, respectively. Key Results: Twenty-two studies on 706 IBS patients and 401 controls were included. Mast cells were increased in the rectosigmoid (SMD: 0.38 [95% CI: 0.06-0.71]; P =.02) and descending colon (SMD: 1.69 [95% CI: 0.65-2.73]; P =.001) of IBS patients. Increased mast cells were observed in both constipation (IBS-C) and diarrhea predominant IBS (IBS-D). CD3+ T cells were increased in the rectosigmoid (SMD: 0.53 [95% CI: 0.21-0.85]; P =.001) and the descending colon of the IBS patients (SMD: 0.79, 95% CI [0.28-1.30]; P =.002). This was possibly in relation to higher CD4+ T cells in IBS (SMD: 0.33 [95% CI: 0.01-0.65]; P =.04) as there were no differences in CD8+ T cells. Conclusions & Inferences: Mast cells and CD3+ T cells are increased in colonic biopsies of patients with IBS vs non-inflamed controls. These changes are segmental and sometimes IBS-subtype dependent. The diagnostic value of the quantification of colonic mucosal cells in IBS requires further investigation. © 2017 John Wiley & Sons Ltd
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