Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation

Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation Publisher Pubmed

Olliaro P^{1, 2} ; Grogl M³ ; Boni M⁴ ; Carvalho EM⁵ ; Chebli H⁶ ; Cisse M⁷ ; Diro E⁸ ; Fernandes Cota G⁹ ; Erber AC¹⁰ ; Gadisa E¹¹ ; Handjani F¹² ; Khamesipour A¹³ ; Llanoscuentas A¹⁴ ; Lopez Carvajal L¹⁵ Show All Authors

Olliaro P^{1, 2}
Grogl M³
Boni M⁴
Carvalho EM⁵
Chebli H⁶
Cisse M⁷
Diro E⁸
Fernandes Cota G⁹
Erber AC¹⁰
Gadisa E¹¹
Handjani F¹²
Khamesipour A¹³
Llanoscuentas A¹⁴
Lopez Carvajal L¹⁵
Grout L¹⁶
Lmimouni BE¹⁷
Mokni M¹⁸
Nahzat MS¹⁹
Ben Salah A²⁰
Ozbel Y²¹
Pascale JM²²
Rizzo Molina N²³
Rode J⁴
Romero G²⁴
Ruizpostigo JA¹⁶
Gore Saravia N²⁵
Soto J²⁶
Uzun S²⁷
Mashayekhi V²⁸
Velez ID¹⁵
Vogt F²⁹
Zerpa O³⁰
Arana B³¹

Source: PLoS Neglected Tropical Diseases Published:2018

Abstract

Introduction: Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown by systematic reviews on old-world and new-world CL (OWCL and NWCL). Materials and methods: Using a previously published guidance paper on CL treatment trial methodology as the reference, consensus was sought on key parameters including core eligibility and outcome measures, among OWCL (7 countries, 10 trial sites) and NWCL (7 countries, 11 trial sites) during two separate meetings. Results: Findings and level of consensus within and between OWCL and NWCL sites are presented and discussed. In addition, CL trial site characteristics and capacities are summarized. Conclusions: The consensus reached allows standardization of future clinical research across OWCL and NWCL sites. We encourage CL researchers to adopt and adapt as required the proposed parameters and outcomes in their future trials and provide feedback on their experience. The expertise afforded between the two sets of clinical sites provides the basis for a powerful consortium with potential for extensive, standardized assessment of interventions for CL and faster approval of candidate treatments. © 2018 Public Library of Science. All Rights Reserved.

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Mahdi Mohebali (9)

Alireza Firooz (3)

Style	Citing Format
MLA	Olliaro P, et al.. "Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation." PLoS Neglected Tropical Diseases, vol. 12, no. 1, 2018, pp. -.
APA	Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, Diro E, Fernandes Cota G, Erber AC, Gadisa E, Handjani F, Khamesipour A, Llanoscuentas A, Lopez Carvajal L, Grout L, Lmimouni BE, Mokni M, Nahzat MS, Ben Salah A, ... Arana B (2018). Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation. PLoS Neglected Tropical Diseases, 12(1), -.
Chicago	Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, Diro E, et al.. "Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation." PLoS Neglected Tropical Diseases 12, no. 1 (2018): -.
Harvard	Olliaro P et al. (2018) 'Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation', PLoS Neglected Tropical Diseases, 12(1), pp. -.
Vancouver	Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, et al.. Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation. PLoS Neglected Tropical Diseases. 2018;12(1):-.
BibTex	@article{ author = {Olliaro P and Grogl M and Boni M and Carvalho EM and Chebli H and Cisse M and Diro E and Fernandes Cota G and Erber AC and Gadisa E and Handjani F and Khamesipour A and Llanoscuentas A and Lopez Carvajal L and Grout L and Lmimouni BE and Mokni M and Nahzat MS and Ben Salah A and Ozbel Y and Pascale JM and Rizzo Molina N and Rode J and Romero G and Ruizpostigo JA and Gore Saravia N and Soto J and Uzun S and Mashayekhi V and Velez ID and Vogt F and Zerpa O and Arana B}, title = {Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation}, journal = {PLoS Neglected Tropical Diseases}, volume = {12}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Olliaro P AU - Grogl M AU - Boni M AU - Carvalho EM AU - Chebli H AU - Cisse M AU - Diro E AU - Fernandes Cota G AU - Erber AC AU - Gadisa E AU - Handjani F AU - Khamesipour A AU - Llanoscuentas A AU - Lopez Carvajal L AU - Grout L AU - Lmimouni BE AU - Mokni M AU - Nahzat MS AU - Ben Salah A AU - Ozbel Y AU - Pascale JM AU - Rizzo Molina N AU - Rode J AU - Romero G AU - Ruizpostigo JA AU - Gore Saravia N AU - Soto J AU - Uzun S AU - Mashayekhi V AU - Velez ID AU - Vogt F AU - Zerpa O AU - Arana B TI - Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation JO - PLoS Neglected Tropical Diseases VL - 12 IS - 1 SP - EP - PY - 2018 ER -

Style

Citing Format

MLA

Olliaro P, et al.. "Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation." PLoS Neglected Tropical Diseases, vol. 12, no. 1, 2018, pp. -.

APA

Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, Diro E, Fernandes Cota G, Erber AC, Gadisa E, Handjani F, Khamesipour A, Llanoscuentas A, Lopez Carvajal L, Grout L, Lmimouni BE, Mokni M, Nahzat MS, Ben Salah A, ... Arana B (2018). Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation. PLoS Neglected Tropical Diseases, 12(1), -.

Chicago

Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, Diro E, et al.. "Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation." PLoS Neglected Tropical Diseases 12, no. 1 (2018): -.

Harvard

Olliaro P et al. (2018) 'Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation', PLoS Neglected Tropical Diseases, 12(1), pp. -.

Vancouver

Olliaro P, Grogl M, Boni M, Carvalho EM, Chebli H, Cisse M, et al.. Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation. PLoS Neglected Tropical Diseases. 2018;12(1):-.

BibTex

@article{ author = {Olliaro P and Grogl M and Boni M and Carvalho EM and Chebli H and Cisse M and Diro E and Fernandes Cota G and Erber AC and Gadisa E and Handjani F and Khamesipour A and Llanoscuentas A and Lopez Carvajal L and Grout L and Lmimouni BE and Mokni M and Nahzat MS and Ben Salah A and Ozbel Y and Pascale JM and Rizzo Molina N and Rode J and Romero G and Ruizpostigo JA and Gore Saravia N and Soto J and Uzun S and Mashayekhi V and Velez ID and Vogt F and Zerpa O and Arana B}, title = {Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation}, journal = {PLoS Neglected Tropical Diseases}, volume = {12}, number = {1}, pages = {-}, year = {2018} }

RIS

TY - JOUR
AU - Olliaro P
AU - Grogl M
AU - Boni M
AU - Carvalho EM
AU - Chebli H
AU - Cisse M
AU - Diro E
AU - Fernandes Cota G
AU - Erber AC
AU - Gadisa E
AU - Handjani F
AU - Khamesipour A
AU - Llanoscuentas A
AU - Lopez Carvajal L
AU - Grout L
AU - Lmimouni BE
AU - Mokni M
AU - Nahzat MS
AU - Ben Salah A
AU - Ozbel Y
AU - Pascale JM
AU - Rizzo Molina N
AU - Rode J
AU - Romero G
AU - Ruizpostigo JA
AU - Gore Saravia N
AU - Soto J
AU - Uzun S
AU - Mashayekhi V
AU - Velez ID
AU - Vogt F
AU - Zerpa O
AU - Arana B
TI - Harmonized Clinical Trial Methodologies for Localized Cutaneous Leishmaniasis and Potential for Extensive Network With Capacities for Clinical Evaluation
JO - PLoS Neglected Tropical Diseases
VL - 12
IS - 1
SP -
EP -
PY - 2018
ER -

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Abstract