Tehran University of Medical Sciences

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Igg4-Related Hypophysitis Publisher Pubmed



Amirbaigloo A1 ; Esfahanian F2 ; Mouodi M2 ; Rakhshani N3 ; Zeinalizadeh M4
Authors

Source: Endocrine Published:2021


Abstract

Hypophysitis is a rare pituitary inflammatory disorder classified in different ways. Immunoglobulin G4-related disease (IgG4-RD), also a rare disease is a systemic fibro-inflammatory condition characterized by infiltration of tissue with IgG4-positive plasma cells; however prevalence of both of them probably is underestimated. In this paper, we present an Iranian patient with biopsy-proven IgG4-related hypophysitis and then review the clinical characteristics, laboratory, imaging, pathologic findings and therapeutic management as well as prognosis of 115 published cases of hypophysitis secondary to IgG4-related disease. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.