Prognostic Factors of Sepsis Rapid Progression in Patients Admitted to Intensive Care Unit Publisher



Roham M¹ ; Abbaszadeh A² ; Zendehdel A³ ; Momeni M⁴ ; Mirzae N⁵ ; Gholami M⁶
Source: Annals of Tropical Medicine and Public Health Published:2017

Abstract

Background: Immediate identification and treatment of patients at the risk of developing sepsis would contribute to a more efficient diagnosis. This study aimed to examine the effective determinants bringing about the rapid progression of this disease towards septic shock and severe sepsis. Materials and Methods: This study is a retrospective cross-sectional research on the patients, above 12 years, admitted to one of the hospitals in Tehran. It took 18 months to conduct this study that included merely patients with sepsis. Patients’ cases were examined thoroughly, and eventually the progression of their diseases towards septic shock (low blood pressure despite adequate fluid intake) or severe sepsis (organ dysfunction) and related factors were investigated. Results: We included 230 patients, among whom 84 individuals developed septic shock and severe sepsis within 72 h. The Effective factors in the progression of their diseases were old age, high temperature, female sex, vascular catheter-related infections, low serum albumin, and diastolic pressure <52 (P = 0.025, 0.04, <0.001, 0.006, <0.001, and <0.001) respectively. Conclusion: A significant number of patients with sepsis developed septic shock and severe sepsis. Our study indicated that factors such as age, sex, low albumin, and low diastolic pressure play major roles in the progression of this disease in patients. © 2018 Annals of Tropical Medicine and Public Health | Published by Wolters Kluwer - Medknow