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Recent Randomized Trials of Antithrombotic Therapy for Patients With Covid-19: Jacc State-Of-The-Art Review Publisher Pubmed



Talasaz AH1, 2 ; Sadeghipour P3 ; Kakavand H1, 2 ; Aghakouchakzadeh M1 ; Kordzadehkermani E1 ; Van Tassell BW4, 5 ; Gheymati A1 ; Ariannejad H2 ; Hosseini SH1 ; Jamalkhani S3 ; Sholzberg M6, 7 ; Monreal M8 ; Jimenez D9 ; Piazza G10 Show All Authors
Authors
  1. Talasaz AH1, 2
  2. Sadeghipour P3
  3. Kakavand H1, 2
  4. Aghakouchakzadeh M1
  5. Kordzadehkermani E1
  6. Van Tassell BW4, 5
  7. Gheymati A1
  8. Ariannejad H2
  9. Hosseini SH1
  10. Jamalkhani S3
  11. Sholzberg M6, 7
  12. Monreal M8
  13. Jimenez D9
  14. Piazza G10
  15. Parikh SA11, 12
  16. Kirtane AJ11, 12
  17. Eikelboom JW13
  18. Connors JM14
  19. Hunt BJ15
  20. Konstantinides SV16, 17
  21. Cushman M18, 19
  22. Weitz JI20, 21
  23. Stone GW11, 22
  24. Krumholz HM23, 24, 25
  25. Lip GYH26, 27
  26. Goldhaber SZ10
  27. Bikdeli B10, 11, 23

Source: Journal of the American College of Cardiology Published:2021


Abstract

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs. © 2021 American College of Cardiology Foundation
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