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Controlled Release Study of Metformin Using Trithiocyanuric Acid Functionalized Mcm-41 As a Nanocarrier Publisher



Hajiaghababaei L1, 2 ; Gholinejad Keshteli P1 ; Badiei A3 ; Hemmati Tirabadi F1 ; Ganjali MR4, 5 ; Mohammadi Ziarani G6
Authors

Source: ChemistrySelect Published:2023


Abstract

Ordered nanoporous silica such as MCM-41 has silanol groups that can be chemically modified to effectively control the release of molecules. In this regard, MCM-41 was functionalized with trithiocyanuric acid groups (TTCA-MCM-41) and offered as a novel carrier to the controlled release of metformin. TTCA-MCM-41 was synthesized and characterized. Thereafter, for 3 hours, saturated metformin solution was contacted with TTCA-MCM-41 to loading of drug. Finally, drug release profile was investigated in simulated body fluid (SBF) and phosphate buffers. The hexagonal symmetry of the TTCA-MCM-41 was confirmed by XRD patterns. The BET surface area, centred on N2 adsorption-desorption, dropped from 846.5 m2/g for the MCM-41 to 295.2 m2/g for the TTCA-MCM-41. With the use of FT-IR spectra, the presence of TTCA groups in the silica system was established. The rope-shaped morphology and the existence of S and N atoms on the MCM-41 are visible in the SEM and EDX. The metformin release from TTCA-MCM-41 exhibits a pH-based behaviour, and release rate was faster at higher pH compared to lower pH in phosphate buffers. In SBF, metformin displayed a steady release rate of around 0.2 mg min−1. The findings demonstrated that TTCA-MCM-41 is a promising candidate as a novel metformin carrier. © 2023 Wiley-VCH GmbH.
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