Asymmetric Dimethylarginine and Soluble Inter-Cellular Adhesion Molecule-1 Serum Levels Alteration Following Ginger Supplementation in Patients With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Zarezadeh M¹ ; Saedisomeolia A¹ ; Khorshidi M⁴ ; Kord Varkane H⁵ ; Makhdoomi Arzati M¹ ; Abdollahi M⁶ ; Yekaninejad MS³ ; Hashemi R² ; Effatpanah M⁷ ; Mohammadzadeh Honarvar N¹
Source: Journal of Complementary and Integrative Medicine Published:2019

Abstract

Patients with type 2 diabetes mellitus (T2DM) are prone to cardiovascular disease (CVD) due to inflammation process and oxidative stress. ADMA (Asymmetric dimethylarginine) and ICAM-1 (inter-cellular adhesion molecule-1) play an important role in CVD pathogenesis. Ginger as an anti-oxidant and anti-inflammation can effect on these biomarkers. The aim of present study was to characterize the effect of ginger supplementation on ADMA and ICAM-1 serum levels in patients with T2DM. The present study is a randomized double-blind clinical trial which is conducted among 45 diabetic patients (nginger=23, nplacebo=22). The participants were randomly divided into two intervention and placebo groups which were received 2?g ginger powder and 2g wheat flour for 10weeks, respectively. ADMA and ICAM-1 concentration were measured by ELISA method. Ginger supplementation decreased ADMA serum levels significantly (P=0.002) and sICAM-1 serum levels marginally (P=0.097) in supplementation group after intervention. No significant difference was observed between placebo and supplementation groups. Present study was conducted among patients with type 2 diabetes mellitus to investigate the effect of ginger supplementation on ADMA and sICAM-1 levels. There was a significant decrement in ADMA serum concentration and slight reduction in sICAM-1 levels in intervention group. The amount of reduction in both biomarkers was not statistically significant in between-groups comparison. © 2019 Walter de Gruyter GmbH, Berlin/Boston.