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Prevalence and Mechanisms of Carbapenem Resistance in Klebsiella Pneumoniae and Escherichia Coli: A Systematic Review and Meta-Analysis of Cross-Sectional Studies From Iran Publisher Pubmed



Nasiri MJ1 ; Mirsaeidi M2 ; Mousavi SMJ1 ; Arshadi M3 ; Fardsanei F4 ; Deihim B5 ; Davoudabadi S1 ; Zamani S6 ; Hajikhani B1 ; Goudarzi H1 ; Goudarzi M1 ; Seghatoleslami ZS7 ; Dabiri H1 ; Tabarsi P8
Authors

Source: Microbial Drug Resistance Published:2020


Abstract

Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) represents an urgent threat worldwide. We aimed to investigate the frequency of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli in Iran. Materials and Methods: PubMed/Medline, Embase, Scopus, Web of Sciences, and Iranian databases were searched to find potentially relevant articles. Statistical analyses were performed using STATA version 14. Results: Forty-nine studies fulfilled the inclusion criteria. The pooled rates of resistance to carbapenem in K. pneumoniae and E. coli were 24.0% (95% confidence interval [CI] 18.0-31.0) and 5.0% (95% CI 2.0-8.0), respectively. blaOXA-48 gene was the most common cause of carbapenem resistance in K. pneumoniae and E. coli. Conclusions: CRE is prevalent in Iran, which confers the importance of strength prevention and control measures. © 2020, Mary Ann Liebert, Inc., publishers 2020.
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