The Variation of Functional Connectivity and Activity Before and After Thalamotomy Surgery (Review) Publisher



Nili MHHK^{1, 2, 3} ; Esfahan SM⁴ ; Bagheri Y^{2, 3} ; Vahabie AH^{1, 2} ; Sanayei M³ ; Ertiaei A⁵ ; Shirani M⁵ ; Dehaqani MRA^{1, 3} ; Rezayat E²
Source: Frontiers in Human Neuroscience Published:2023

Abstract

Ablation surgeries are utilized to treat certain brain disorders. Recently, these surgeries have become more prevalent using techniques such as magnetic resonance guided focused ultrasound (MRgFUS) ablation and Gamma knife thalamotomy (GKT). However, as the thalamus plays a critical role in cognitive functions, the potential impact of these surgeries on functional connectivity and cognition is a matter of concern. Various approaches have been developed to locate the target for ablation and also investigate changes in functional connectivity before and after surgery. Functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) are widely used methods for assessing changes in functional connectivity and activity in clinical research. In this Review, we summarize the use of fMRI and EEG in thalamotomy surgeries. Our analysis shows that thalamotomy surgery can result in changes in functional connectivity in motor-related, visuomotor, and default-mode networks, as detected by fMRI. EEG data also indicate a reduction in over-activities observed in the preoperative state. Copyright © 2023 Nili, Esfahan, Bagheri, Vahabie, Sanayei, Ertiaei, Shirani, Dehaqani and Rezayat.