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Htlv-1 Infection and Micrornas: Unraveling the Complex Crosstalk Publisher



Edalat F1 ; Letafati A2, 3 ; Kaghazchi T3 ; Sadeghi M3 ; Taheri A4 ; Shikki A5 ; Garkani SH3 ; Afrozi M3 ; Norouzi M2 ; Mozhgani SH6
Authors

Source: Infectious Agents and Cancer Published:2025


Abstract

Human T-cell leukemia virus type 1 (HTLV-1) retrovirus that infects millions of individuals worldwide, have caused severe diseases like adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite extensive research efforts, the underlying mechanisms leading to HTLV-1 pathogenesis remain incompletely understood. New research has revealed that microRNAs (miRNAs) play a crucial role in the complex interplay between HTLV-1 infection and host cellular responses. This review highlights the multifaceted interactions between HTLV-1 and miRNAs, encompassing both viral manipulation of cellular miRNA networks and host miRNA-mediated responses. Gaining a comprehensive understanding of the complex interconnection between HTLV-1 infection and miRNAs provides a significant opportunity for discovering innovative therapeutic approaches and creating advanced diagnostic tools aimed in HTLV-1 treatment. © The Author(s) 2025.
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