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Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives Publisher



Azarkamanzad Z1 ; Farzaneh F1 ; Ghandi M2 ; Feizabadi MM3 ; Jasemi S3
Authors

Source: Russian Journal of Organic Chemistry Published:2022


Abstract

Abstract: Four pyranopyrimidinedione derivatives were prepared through a one-pot pseudo-three-component acetic acid-catalyzed reaction of 6-amino-1,3-dimethyluracil with 2-hydroxybenzaldehydes. The synthesized compounds were evaluated for their antibacterial activity against a panel of bacterial strains. The minimum inhibitory concentrations (MICs) were determined using broth microdilution assay according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. With the exception of 5-methoxy derivative, the other pyranopyrimidinediones exhibited antibacterial activities against all tested bacterial cultures. The most potent antibacterial effect was observed for 5-bromopyranopyrimidinedione derivative against clinical strains, which can be regarded as promising. © 2022, Pleiades Publishing, Ltd.
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