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Building a Cancer Biobank in a Low-Resource Setting in Northern Iran: The Golestan Cancer Biobank Publisher Pubmed



Ghasemikebria F1 ; Jafaridelouie N1 ; Amiriani T1 ; Norouzi A1 ; Abediardekani B2 ; Nasrollahzadeh D2, 3 ; Ashaari M4 ; Besharat S1 ; Naeimitabiei M5 ; Gharanjic I1 ; Babapalangi Z1 ; Poustchi H3 ; Semnani S1, 6 ; Fazel A5 Show All Authors
Authors
  1. Ghasemikebria F1
  2. Jafaridelouie N1
  3. Amiriani T1
  4. Norouzi A1
  5. Abediardekani B2
  6. Nasrollahzadeh D2, 3
  7. Ashaari M4
  8. Besharat S1
  9. Naeimitabiei M5
  10. Gharanjic I1
  11. Babapalangi Z1
  12. Poustchi H3
  13. Semnani S1, 6
  14. Fazel A5
  15. Kozlakidis Z7
  16. Weiderpass E8
  17. Roshandel G1

Source: Archives of Iranian Medicine Published:2021


Abstract

Background: We aim to present the development and the initial results of the Golestan Cancer Biobank (GoCB), in a low resource setting in northern Iran. Methods: The GoCB protocol and its standard operation procedures (SOP) were developed according to internationally accepted standards and protocols with some modifications considering the limited resources in our setting. The main biological samples collected by the GoCB include blood sample, urine sample, fresh endoscopy tissue sample, fresh surgical tissue sample and formalin fixed paraffin embedded (FFPE) tissue sample. The GoCB collects patients' demographic data, tumor characteristics as well as data on risk factors. We developed a specific GoCB software for management of patient data and biological sample information. The GoCB dataset is annually linked with the Golestan cancer registry dataset to add complementary data (e.g., survival data). Results: The GoCB started collection of data and biological samples in December 2016. By November 2020, a total number of 1217 cancer patients participated in the GoCB. The majority of the GoCB participants (n = 942, 77%) were those with gastrointestinal and breast cancers. Data on risk factors were successfully collected in 684 (56.2%) of the participants. Overall, 3563 samples were collected from the GoCB participants and 730 samples were used in 7 national and international research projects. Conclusion: We considered specific strategies to overcome major limitations, especially budget shortage, in the development and maintenance of a cancer-specific biological repositories in our setting. The GoCB may be considered as a model for the development of biobank in low- and middle-income countries (LMICs). © 2021 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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