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1,3-Enynes in Transition Metal Catalysis: Allene Synthesis, Functionalization, and Annulation Publisher Pubmed



Doraghi F ; Edareh MH ; Ghasemi M ; Larijani B ; Mahdavi M ; Alharrasi A
Authors

Source: Chemical Record Published:2026


Abstract

The high reactivity and immediate accessibility of 1,3-enynes render them versatile foundational units in the synthesis of highly valuable molecular structures, encompassing propargylic, allene, and diene compounds, in addition to carbo- and heterocyclic compounds. Transition-metal catalyzed 1,4-difunctionalization of 1,3-enynes represents one of the most powerful approaches that has attracted the attention of chemists. In this review, the functionalization and annulation reactions of 1,3-enynes under various transition metal-catalyzed systems are highlighted. © 2025 The Chemical Society of Japan and Wiley-VCH GmbH.