Evaluation of Serum Oxidized Low-Density Lipoproteinin Renal Transplant Recipients and Hemodialysis Patients and Relation With Involved Variables Publisher Pubmed



Soltani A¹ ; Argani H² ; Soleimani F¹ ; Rahimipour H⁴ ; Akbarzadehbaghban A³ ; Azizi T² ; Kazerouni F¹ ; Farshchian F¹
Source: Experimental and Clinical Transplantation Published:2015

Abstract

Objectives: Disturbances in metabolism of lipoproteins and oxidative modification of low-density lipoprotein contribute to cardiovascular disease and development of oxidative stress in patients under renal replacement therapy (hemodialysis and renal transplant). This study was designed to compare oxidized low-density lipoprotein levels and lipid profiles in renal transplant recipients and hemodialysis patients. Materials and Methods: We investigated the concentration of oxidized low-density lipoprotein in hemodialysis (n = 38) and renal transplant (n = 59) patients who had no active inflammatory disease, liver disease, or malignancy, and results were compared to a control group (n = 30). Results: Renal transplant recipients had hypercholesterolemia, hypertriglyceridemia, and increased oxidized low-density lipoprotein levels (P = .019) compared with the control group. Hemodialysis patients had moderate hypertriglyceridemia (not significant), hypercholesterolemia, decrease in highdensity lipoprotein, and increase in oxidized lowdensity lipoprotein levels (P < .0001) compared with the control group. In the renal transplant group, oxidized low-density lipoprotein level had a negative correlation with the duration after transplant (r = -0. 407; P = .026), positive association with cyclosporine level (r = 0. 288; P = .04), and negative correlation with high-density lipoprotein level (r = -0. 30; P = .05); oxidized low-density lipoprotein/ high-density lipoprotein ratio also had a positive correlation with cyclosporine level (r = 0. 309; P = .027) and negative correlation with high-density lipoprotein level (r = -0. 72; P < .001) in the renal transplant group and high-density lipoprotein in the hemodialysis group (r = -0. 87; P < .001). Multiple stepwise regression analyses showed that oxidized low-density lipoprotein only was associated with cyclosporine level (R2 = 0. 155; β= 0. 393; P = .024). Conclusions: History of cardiovascular disease is the most important factor associated with end-stage renal disease, and high oxidized low-density lipoprotein level, oxidized low-density lipoprotein/ high-density lipoprotein ratio, and highdensity lipoprotein level may affect cardiovascular disease. © Baskent University 2015 Printed in Turkey. All Rights Reserved.