Antioxidant Effects of Selenium in Adult Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher



Hasani M^{1, 2} ; Agh F³ ; Irandoost P⁴ ; Farsi F⁵ ; Khodabakhshi A⁶ ; Heshmati J⁷ ; Pizarro AB⁸ ; Aghamohamadi V⁹ ; Khazdouz M^{4, 10, 11}
Source: Topics in Clinical Nutrition Published:2023

Abstract

Oxidative stress is the fundamental etiology of inflammation and organ failure, and unfavorable consequences characterize critical illness. We searched systematically up to September 2021 to find related randomized controlled trials (RCTs) that investigated the effects of selenium in antioxidant markers of the critically ill. A total of 10 RCTs were included. The results indicated that selenium administration has no significant effects on glutathione peroxidase activity (standardized mean difference [SMD]: 1.67, 95% confidence interval [CI]: -0.01 to 3.35) and C-reactive protein levels (SMD: -0.21 mg/L, 95% CI: -0.45 to 0.03). Further trials are needed to prove the potential effects of selenium administration on antioxidant and inflammation markers. © 2023 Lippincott Williams and Wilkins. All rights reserved.