Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells

Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells Publisher Pubmed

Momeny M¹ ; Moghaddaskho F¹ ; Gortany NK² ; Yousefi H³ ; Sabourinejad Z⁴ ; Zarrinrad G¹ ; Mirshahvaladi S⁵ ; Eyvani H¹ ; Barghi F¹ ; Ahmadinia L¹ ; Ghazikhansari M² ; Dehpour AR² ; Amanpour S⁶ ; Tavangar SM⁴ Show All Authors

Momeny M¹
Moghaddaskho F¹
Gortany NK²
Yousefi H³
Sabourinejad Z⁴
Zarrinrad G¹
Mirshahvaladi S⁵
Eyvani H¹
Barghi F¹
Ahmadinia L¹
Ghazikhansari M²
Dehpour AR²
Amanpour S⁶
Tavangar SM⁴
Dardaei L⁷
Emami AH⁸
Alimoghaddam K¹
Ghavamzadeh A¹
Ghaffari SH¹

Source: Scientific Reports Published:2017

Abstract

Glioblastoma (GBM) remains one of the most fatal human malignancies due to its high angiogenic and infiltrative capacities. Even with optimal therapy including surgery, radiotherapy and temozolomide, it is essentially incurable. GBM is among the most neovascularised neoplasms and its malignant progression associates with striking neovascularisation, evidenced by vasoproliferation and endothelial cell hyperplasia. Targeting the pro-angiogenic pathways is therefore a promising anti-glioma strategy. Here we show that tivozanib, a pan-inhibitor of vascular endothelial growth factor (VEGF) receptors, inhibited proliferation of GBM cells through a G2/M cell cycle arrest via inhibition of polo-like kinase 1 (PLK1) signalling pathway and down-modulation of Aurora kinases A and B, cyclin B1 and CDC25C. Moreover, tivozanib decreased adhesive potential of these cells through reduction of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Tivozanib diminished GBM cell invasion through impairing the proteolytic cascade of cathepsin B/urokinase-type plasminogen activator (uPA)/matrix metalloproteinase-2 (MMP-2). Combination of tivozanib with EGFR small molecule inhibitor gefitinib synergistically increased sensitivity to gefitinib. Altogether, these findings suggest that VEGFR blockade by tivozanib has potential anti-glioma effects in vitro. Further in vivo studies are warranted to explore the anti-tumour activity of tivozanib in combinatorial approaches in GBM.

Related Docs

View other Related Docs

1. Cediranib, a Pan-Inhibitor of Vascular Endothelial Growth Factor Receptors, Inhibits Proliferation and Enhances Therapeutic Sensitivity in Glioblastoma Cells, Life Sciences (2021)

2. Anti-Tumour Activity of Tivozanib, a Pan-Inhibitor of Vegf Receptors, in Therapy-Resistant Ovarian Carcinoma Cells, Scientific Reports (2017)

3. The Role of Kinase Signaling in Resistance to Bevacizumab Therapy for Glioblastoma Multiforme, Cancer Biotherapy and Radiopharmaceuticals (2019)

Experts (# of related papers)

View all Related Experts

Seyed Hamidollah Ghaffari (6)

Ahmad Reza Dehpour (3)

Style	Citing Format
MLA	Momeny M, et al.. "Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells." Scientific Reports, vol. 7, no. , 2017, pp. -.
APA	Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, Mirshahvaladi S, Eyvani H, Barghi F, Ahmadinia L, Ghazikhansari M, Dehpour AR, Amanpour S, Tavangar SM, Dardaei L, Emami AH, Alimoghaddam K, Ghavamzadeh A, Ghaffari SH (2017). Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells. Scientific Reports, 7(), -.
Chicago	Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, Mirshahvaladi S, et al.. "Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells." Scientific Reports 7, no. (2017): -.
Harvard	Momeny M et al. (2017) 'Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells', Scientific Reports, 7(), pp. -.
Vancouver	Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, et al.. Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells. Scientific Reports. 2017;7():-.
BibTex	@article{ author = {Momeny M and Moghaddaskho F and Gortany NK and Yousefi H and Sabourinejad Z and Zarrinrad G and Mirshahvaladi S and Eyvani H and Barghi F and Ahmadinia L and Ghazikhansari M and Dehpour AR and Amanpour S and Tavangar SM and Dardaei L and Emami AH and Alimoghaddam K and Ghavamzadeh A and Ghaffari SH}, title = {Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells}, journal = {Scientific Reports}, volume = {7}, number = {}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Momeny M AU - Moghaddaskho F AU - Gortany NK AU - Yousefi H AU - Sabourinejad Z AU - Zarrinrad G AU - Mirshahvaladi S AU - Eyvani H AU - Barghi F AU - Ahmadinia L AU - Ghazikhansari M AU - Dehpour AR AU - Amanpour S AU - Tavangar SM AU - Dardaei L AU - Emami AH AU - Alimoghaddam K AU - Ghavamzadeh A AU - Ghaffari SH TI - Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells JO - Scientific Reports VL - 7 IS - SP - EP - PY - 2017 ER -

Style

Citing Format

MLA

Momeny M, et al.. "Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells." Scientific Reports, vol. 7, no. , 2017, pp. -.

APA

Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, Mirshahvaladi S, Eyvani H, Barghi F, Ahmadinia L, Ghazikhansari M, Dehpour AR, Amanpour S, Tavangar SM, Dardaei L, Emami AH, Alimoghaddam K, Ghavamzadeh A, Ghaffari SH (2017). Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells. Scientific Reports, 7(), -.

Chicago

Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, Mirshahvaladi S, et al.. "Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells." Scientific Reports 7, no. (2017): -.

Harvard

Momeny M et al. (2017) 'Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells', Scientific Reports, 7(), pp. -.

Vancouver

Momeny M, Moghaddaskho F, Gortany NK, Yousefi H, Sabourinejad Z, Zarrinrad G, et al.. Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells. Scientific Reports. 2017;7():-.

BibTex

@article{ author = {Momeny M and Moghaddaskho F and Gortany NK and Yousefi H and Sabourinejad Z and Zarrinrad G and Mirshahvaladi S and Eyvani H and Barghi F and Ahmadinia L and Ghazikhansari M and Dehpour AR and Amanpour S and Tavangar SM and Dardaei L and Emami AH and Alimoghaddam K and Ghavamzadeh A and Ghaffari SH}, title = {Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells}, journal = {Scientific Reports}, volume = {7}, number = {}, pages = {-}, year = {2017} }

RIS

TY - JOUR
AU - Momeny M
AU - Moghaddaskho F
AU - Gortany NK
AU - Yousefi H
AU - Sabourinejad Z
AU - Zarrinrad G
AU - Mirshahvaladi S
AU - Eyvani H
AU - Barghi F
AU - Ahmadinia L
AU - Ghazikhansari M
AU - Dehpour AR
AU - Amanpour S
AU - Tavangar SM
AU - Dardaei L
AU - Emami AH
AU - Alimoghaddam K
AU - Ghavamzadeh A
AU - Ghaffari SH
TI - Blockade of Vascular Endothelial Growth Factor Receptors by Tivozanib Has Potential Anti-Tumour Effects on Human Glioblastoma Cells
JO - Scientific Reports
VL - 7
IS -
SP -
EP -
PY - 2017
ER -

Science Communicator Platform

Authors

Abstract