Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Signaling Pathways Governing the Behaviors of Leukemia Stem Cells Publisher



Azizidoost S1 ; Nasrolahi A2 ; Sheykhisabzehpoush M3 ; Anbiyaiee A4 ; Khoshnam SE5 ; Farzaneh M6 ; Uddin S7
Authors

Source: Genes and Diseases Published:2024


Abstract

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis. © 2023 Chongqing Medical University
Related Docs
View other Related Docs
1. Chronic Myeloid Leukemia Stem Cells: Targeting Therapeutic Implications, Stem Cell Research and Therapy (2021)
2. Glance Into Cancer Stem Cells, Journal of Kerman University of Medical Sciences (2016)
3. Molecular Docking As a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes, Frontiers in Pharmacology (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Alimohammad Alizadeh (1)
Other Related Docs
4. Microrna in Leukemia: Tumor Suppressors and Oncogenes With Prognostic Potential, Journal of Cellular Physiology (2019)
5. The Hippo Signaling Pathway in Leukemia: Function, Interaction, and Carcinogenesis, Cancer Cell International (2021)
6. Cancer Stem Cell Research in Iran: Potentials and Challenges, Future Oncology (2017)
7. The Promising Role of Non-Coding Rnas As Biomarkers and Therapeutic Targets for Leukemia, Genes (2023)
8. Studying the Potential of Upregulated Ptgs2 and Vegf-C Besides Hyper-Methylation of Ptgs2 Promoter As Biomarkers of Acute Myeloid Leukemia, Molecular Biology Reports (2022)
9. Advances in Epigenetic Treatment of Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review, Clinical Epigenetics (2025)
10. Targeting Hedgehog Signaling Pathway: Paving the Road for Cancer Therapy, Pharmacological Research (2019)
11. The Role of Notch Signaling in Bone Marrow Niche, Hematology (2015)
12. Naturally Occurring Compounds Acting As Potent Anti-Metastatic Agents and Their Suppressing Effects on Hedgehog and Wnt/Β-Catenin Signalling Pathways, Cell Proliferation (2017)
13. Update on Immune-Based Therapy Strategies Targeting Cancer Stem Cells, Cancer Medicine (2023)
14. Hypoxia Inducible Factors in the Tumor Microenvironment As Therapeutic Targets of Cancer Stem Cells, Life Sciences (2019)
15. Mesenchymal Stem Cells in the Bone Marrow Microenvironment: A Double-Edged Sword for Aml, Journal of Cancer Research and Clinical Oncology (2025)
16. Pediatric Acute Lymphoblastic Leukemia Management Using Multitargeting Bioactive Natural Compounds: A Systematic and Critical Review, Pharmacological Research (2022)
17. Autophagy Induced by Metabolic Processes Leads to Solid Tumor Cell Metastatic Dormancy and Recurrence, Medical Oncology (2025)
18. A Review on Leukemia and Ipsc Technology: Application in Novel Treatment and Future, Current Stem Cell Research and Therapy (2018)
19. Advancing the Therapeutic Effectiveness of Paclitaxel in Chronic Lymphocytic Leukemia Through the Simultaneous Inhibition of Notch1 and Sf3b1, Cancer Cell International (2025)
20. Investigating the Inhibitory Effect of Mir-34A, Mir-449A, Mir-1827, and Mir-106B on Target Genes Including Notch1, C-Myc, and Ccnd1 in Human T Cell Acute Lymphoblastic Leukemia Clinical Samples and Cell Line, Iranian Journal of Basic Medical Sciences (2020)