Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting

Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting Publisher

Assadiasl S ; Soleimanifar N ; Alamolhoda MH ; Mojtahedi H ; Sadr M ; Safdel S ; Mozooni Z ; Nicknam MH

Source: International Journal of Nutrition Sciences Published:2026

Abstract

Background: Intermittent fasting (IF) is a 16/8 fasting model, which is supposed to recruit immune cells to the bone marrow, thus prevents immune exhaustion. The aim of this study was to compare the frequency of naive, memory, and effector T lymphocytes in blood circulation before and after IF. Methods: Proportion of CD4+CXCR7+CD45RA+ (naive T cells), CD4+CXCR7+CD45RA-(memory T cells), and CD4+CXCR7-CD45RA-(effector T cells) cells were evaluated in 18 healthy young men in the week before and on the last day of Ramadan fasting, resembling IF, using flowcytometry. Results: The percentage of peripheral blood naive T cells reduced significantly at the end of Ramadan fasting (p=0.001); however, the frequency of memory and effector T cells did not change. Conclusion: The decreased number of circulatory naive T cells suggests a protective effect of intermittent fasting on immunosenescence and immune exhaustion. Also, preserved proportion of effector T cells is suggestive of an intact immunocompetence despite 4 weeks of IF. © International Journal of Nutrition Sciences.

Style	Citing Format
MLA	Assadiasl S, et al.. "Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting." International Journal of Nutrition Sciences, vol. 11, no. 1, 2026, pp. 152-158.
APA	Assadiasl S, Soleimanifar N, Alamolhoda MH, Mojtahedi H, Sadr M, Safdel S, Mozooni Z, Nicknam MH (2026). Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting. International Journal of Nutrition Sciences, 11(1), 152-158.
Chicago	Assadiasl S, Soleimanifar N, Alamolhoda MH, Mojtahedi H, Sadr M, Safdel S, Mozooni Z, Nicknam MH. "Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting." International Journal of Nutrition Sciences 11, no. 1 (2026): 152-158.
Harvard	Assadiasl S et al. (2026) 'Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting', International Journal of Nutrition Sciences, 11(1), pp. 152-158.
Vancouver	Assadiasl S, Soleimanifar N, Alamolhoda MH, Mojtahedi H, Sadr M, Safdel S, et al.. Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting. International Journal of Nutrition Sciences. 2026;11(1):152-158.
BibTex	@article{ author = {Assadiasl S and Soleimanifar N and Alamolhoda MH and Mojtahedi H and Sadr M and Safdel S and Mozooni Z and Nicknam MH}, title = {Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting}, journal = {International Journal of Nutrition Sciences}, volume = {11}, number = {1}, pages = {152-158}, year = {2026} }
RIS	TY - JOUR AU - Assadiasl S AU - Soleimanifar N AU - Alamolhoda MH AU - Mojtahedi H AU - Sadr M AU - Safdel S AU - Mozooni Z AU - Nicknam MH TI - Naive, Effector, and Memory T Cells Frequency in the Peripheral Blood of Healthy Men Following 4 Weeks of Intermittent Fasting JO - International Journal of Nutrition Sciences VL - 11 IS - 1 SP - 152 EP - 158 PY - 2026 ER -

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