Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy

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Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy Publisher Pubmed

Shirvani G¹ ; Shockravi A² ; Amini M³ ; Saemian N¹

Source: Journal of Labelled Compounds and Radiopharmaceuticals Published:2017

Abstract

Metallo-beta-lactamase enzymes make bacteria resistant to a broad range of commonly used beta-lactam antibiotics. Several thiol derivatives of L-amino acids have been shown their inhibitory effects against the metallo-β-lactamase IMP-1. In this study, (2-mercaptoacetyl)-L-tryptophan as a new inhibitor of metallo-β-lactamases labeled with carbon-14 in the 2-position of the indole ring was prepared from [2-14C]indole as a key synthetic intermediate based on chiral pool strategy. The overall synthesis was performed in 10 steps with the overall radiochemical yield 3.6% on the basis of the barium [14C]carbonate as a starting material. Copyright © 2016 John Wiley & Sons, Ltd.

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Style	Citing Format
MLA	Shirvani G, et al.. "Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy." Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 2, 2017, pp. 130-134.
APA	Shirvani G, Shockravi A, Amini M, Saemian N (2017). Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy. Journal of Labelled Compounds and Radiopharmaceuticals, 60(2), 130-134.
Chicago	Shirvani G, Shockravi A, Amini M, Saemian N. "Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy." Journal of Labelled Compounds and Radiopharmaceuticals 60, no. 2 (2017): 130-134.
Harvard	Shirvani G et al. (2017) 'Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy', Journal of Labelled Compounds and Radiopharmaceuticals, 60(2), pp. 130-134.
Vancouver	Shirvani G, Shockravi A, Amini M, Saemian N. Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy. Journal of Labelled Compounds and Radiopharmaceuticals. 2017;60(2):130-134.
BibTex	@article{ author = {Shirvani G and Shockravi A and Amini M and Saemian N}, title = {Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy}, journal = {Journal of Labelled Compounds and Radiopharmaceuticals}, volume = {60}, number = {2}, pages = {130-134}, year = {2017} }
RIS	TY - JOUR AU - Shirvani G AU - Shockravi A AU - Amini M AU - Saemian N TI - Synthesis of (2-Mercaptoacetyl)-L-[2-14C]Tryptophan As a Selective Metallo-Β-Lactamase Inhibitor Via [2-14C]Indole Based on Chiral Pool Strategy JO - Journal of Labelled Compounds and Radiopharmaceuticals VL - 60 IS - 2 SP - 130 EP - 134 PY - 2017 ER -

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