Preimplantation Factor (Pif): A Peptide With Various Functions Publisher Pubmed



Zare F^{1, 2} ; Seifati SM¹ ; Dehghanmanshadi M³ ; Fesahat F¹
Source: Jornal Brasileiro de Reproducao Assistida Published:2020

Abstract

Preimplantation Factor (PIF) is a novel fifteen amino acid linear peptide (MVRIKPGSANKPSDD), which has different biological functions in mammalian species e.g. its role in neuron restoration, pregnancy and related disor-ders, and also in autoimmune diseases. Since all clinical studies have shown that PIF has both local and systemic effects, it can be considered as an integrated therapy for the treatment of inflammation conditions, along with the prevention of advanced disease. The synthetic PIF (sPIF) analog is a good representative of native PIF action, and it regulates peripheral immune cells to achieve endurance without immune suppression-an effective agent in non-pregnant autoimmune models. This study provides infor-mation, from evidence-based studies so far about PIF’s different functional aspects. © 2020, Sociedade Brasileira de Reproducao Assistida. All rights reserved.