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The Effect of Intrathecal Delivery of Bone Marrow Stromal Cells on Hippocampal Neurons in Rat Model of Alzheimer’S Disease



Eftekharzadeh M1 ; Nobakht M1, 2 ; Alizadeh A3 ; Soleimani M1, 2, 7 ; Hajghasem M4 ; Shargh BK5 ; Osguei NK6 ; Behnam B2, 7 ; Samadikuchaksaraei A2, 8, 9
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Source: Iranian Journal of Basic Medical Sciences Published:2015

Abstract

Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of ß amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer’s disease in rat model. © 2015, Iranian Journal of Basic Medical Sciences. All rights reserved.
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