Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Effect of Intrathecal Delivery of Bone Marrow Stromal Cells on Hippocampal Neurons in Rat Model of Alzheimer’S Disease



Eftekharzadeh M1 ; Nobakht M1, 2 ; Alizadeh A3 ; Soleimani M1, 2, 7 ; Hajghasem M4 ; Shargh BK5 ; Osguei NK6 ; Behnam B2, 7 ; Samadikuchaksaraei A2, 8, 9
Authors

Source: Iranian Journal of Basic Medical Sciences Published:2015

Abstract

Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of ß amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer’s disease in rat model. © 2015, Iranian Journal of Basic Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Mesenchymal Stem Cells Act As Stimulators of Neurogenesis and Synaptic Function in a Rat Model of Alzheimer's Disease, Heliyon (2021)
2. Mesenchymal Stromal Cells (Mscs) for Neurodegenerative Disease: A Promising Frontier, European Journal of Cell Biology (2020)
3. Dose-Dependent Neuroprotective Effects of Adipose-Derived Mesenchymal Stem Cells on Amyloid Β-Induced Alzheimer's Disease in Rats, Biochemical and Biophysical Research Communications (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Sharifzadeh (2)
Mina Ranjbaran (2)
Other Related Docs
4. Long-Term Behavioral, Histological, Biochemical and Hematological Evaluations of Amyloid Beta-Induced Alzheimer’S Disease in Rat, Acta Neurobiologiae Experimentalis (2018)
5. Preconditioning Adipose-Derived Mesenchymal Stem Cells With Dimethyl Fumarate Promotes Their Therapeutic Efficacy in the Brain Tissues of Rats With Alzheimer's Disease, Biochemical and Biophysical Research Communications (2023)
6. Neuroprotective Effect of New Nanochelating-Based Nano Complex, Alzc3, Against Aβ (1–42)-Induced Toxicity in Rat: A Comparison With Memantine, Pharmaceutical Research (2020)
7. Determination of the Best Concentration of Streptozotocin to Create a Diabetic Brain Using Histological Techniques, Journal of Molecular Neuroscience (2016)
8. Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model, Pharmaceutical Sciences (2020)
9. Development and Validation of Alzheimer’S Disease Animal Model for the Purpose of Regenerative Medicine, Cell and Tissue Banking (2019)
10. The Correlation of Serum S100β Protein Levels and Hippocampal Seladin-1 Gene Expression in a Rat Model of Sporadic Alzheimer’S Disease, Tehran University Medical Journal (2015)
11. Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
12. Brain Homogenate of a Rat Model of Alzheimer Disease Modifies the Secretome of 3D Cultured Periodontal Ligament Stem Cells: A Potential Neuroregenerative Therapy, Iranian Journal of Pharmaceutical Research (2022)
13. Stem Cell in Neurodegenerative Disorders; an Emerging Strategy, International Journal of Developmental Neuroscience (2021)
14. Emerging Stem Cell Therapy and Tissue Engineering-Based Approaches in Neurodegenerative Diseases, Handbook of Stem Cell Applications (2024)
15. Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis, Iranian Biomedical Journal (2015)
16. Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat, Behavioural Neurology (2016)
17. Extracellular Vesicles As a Neprilysin Delivery System Memory Improvement in Alzheimer’S Disease, Iranian Journal of Pharmaceutical Research (2020)
18. Stem Cell- and Gene-Based Therapies As Potential Candidates in Alzheimer's Therapy, Journal of Cellular Biochemistry (2018)
19. A Focus on Allogeneic Mesenchymal Stromal Cells As a Versatile Therapeutic Tool for Treating Multiple Sclerosis, Stem Cell Research and Therapy (2021)
20. Protective Effect of Iris Germanica L. in Β-Amyloid-Induced Animal Model of Alzheimer’S Disease, African Journal of Traditional# Complementary and Alternative Medicines (2017)