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Review on Approved and Inprogress Covid-19 Vaccines Publisher



Farnudianhabibi A1, 2 ; Mirjani M1, 2 ; Montazeri V3 ; Aliebrahimi S4 ; Katouzian I5 ; Abdolhosseini S6 ; Rahmani A1, 2 ; Keyvani H7 ; Ostad SN8 ; Radmalekshahi M1, 2
Authors

Source: Iranian Journal of Pharmaceutical Research Published:2022


Abstract

The last generation of Coronavirus named COVID-19 is responsible for the recent worldwide outbreak. Concerning the widespread and quick predominance, there is a critical requirement for designing appropriate vaccines to surmount this grave problem. Correspondingly, in this revision, COVID-19 vaccines (which are being developed until March 29th, 2021) are classified into specific and non-specific categories. Specific vaccines comprise genetic-based vaccines (mRNA, DNA), vector-based, protein/recombinant protein vaccines, inactivated viruses, live-attenuated vaccines, and novel strategies including microneedle arrays (MNAs), and nanoparticles vaccines. Moreover, specific vaccines such as BCG, MRR, and a few other vaccines are considered Non-specific. What is more, according to the significance of Bioinformatic sciences in the cutting-edge vaccine design and rapid outbreak of COVID-19, herein, Bioinformatic principles including reverse vaccinology, epitopes prediction/selection and, their further applications in the design of vaccines are discussed. Last but not least, safety, challenges, advantages, and future prospects of COVID-19 vaccines are highlighted. © 2022, Author(s).
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