Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits

Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits Publisher Pubmed

Aghaei H¹ ; Kheirkhah A² ; Alizadeh AM³ ; Eshaghi A¹ ; Aliakbarnavahi R¹ ; Keikha Z⁴ ; Chaibakhsh S¹

Source: BMC Ophthalmology Published:2023

Abstract

Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe. © 2023, The Author(s).

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Style	Citing Format
MLA	Aghaei H, et al.. "Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits." BMC Ophthalmology, vol. 23, no. 1, 2023, pp. -.
APA	Aghaei H, Kheirkhah A, Alizadeh AM, Eshaghi A, Aliakbarnavahi R, Keikha Z, Chaibakhsh S (2023). Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits. BMC Ophthalmology, 23(1), -.
Chicago	Aghaei H, Kheirkhah A, Alizadeh AM, Eshaghi A, Aliakbarnavahi R, Keikha Z, Chaibakhsh S. "Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits." BMC Ophthalmology 23, no. 1 (2023): -.
Harvard	Aghaei H et al. (2023) 'Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits', BMC Ophthalmology, 23(1), pp. -.
Vancouver	Aghaei H, Kheirkhah A, Alizadeh AM, Eshaghi A, Aliakbarnavahi R, Keikha Z, et al.. Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits. BMC Ophthalmology. 2023;23(1):-.
BibTex	@article{ author = {Aghaei H and Kheirkhah A and Alizadeh AM and Eshaghi A and Aliakbarnavahi R and Keikha Z and Chaibakhsh S}, title = {Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits}, journal = {BMC Ophthalmology}, volume = {23}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Aghaei H AU - Kheirkhah A AU - Alizadeh AM AU - Eshaghi A AU - Aliakbarnavahi R AU - Keikha Z AU - Chaibakhsh S TI - Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits JO - BMC Ophthalmology VL - 23 IS - 1 SP - EP - PY - 2023 ER -

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