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Gut Micobiota Alteration by Lactobacillus Rhamnosus Reduces Pro-Inflammatory Cytokines and Glucose Level in the Adult Model of Zebrafish Publisher Pubmed



Bootorabi F1 ; Saadat F2 ; Falak R3 ; Manouchehri H4 ; Changizi R4 ; Mohammadi H5 ; Safavifar F6 ; Khorramizadeh MR1, 6
Authors

Source: BMC Research Notes Published:2021


Abstract

Objective: Type 2 diabetes mellitus (T2DM) is still a challenge for physicians to manage patient’s circumstances. It is assumed that alterations in the normal flora may be involved in the pathogenesis of T2DM through inducing chronic inflammation. To investigate the effect of Lactobacillus rhamnosus as a common probiotic on T2DM, we induced an experimental model of T2DM in adult male Zebrafish by gradient hyper-glucose accumulation methodology. Results: In this trial 3-month old male adult Zebrafish were divided in to four groups including two control groups and T2DM induced groups with or without probiotic treatment. After 5 days of acclimation, T2DM was induced by a gradient hyper-glucose accumulation methodology. Diabetic fishes had statistically abnormal blood glucose and pro-inflammatory cytokine levels compared to control group (p = 0.0001). These results suggest that probiotic intervention decreased the blood glucose level in the T2DM-P group by decreasing pro-inflammatory cytokines responsible for signaling in T2DM therapeutic modalities. © 2021, The Author(s).
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