Targeted Delivery of Anticancer Drug Loaded Charged Plga Polymeric Nanoparticles Using Electrostatic Field Publisher Pubmed



Miraghaie SH^{1, 2, 3} ; Zandi A^{2, 4} ; Davari Z^{2, 3} ; Mousavikiasary MS² ; Saghafi Z² ; Gilani A² ; Kordehlachin Y² ; Shojaeian F^{2, 5} ; Mamdouh A² ; Heydari Z⁶ ; Dorkoosh FA³ ; Kaffashi B⁷ ; Abdolahad M^{2, 3, 8}
Source: Macromolecular Bioscience Published:2023

Abstract

Pure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with negatively charged poly(lactide-co-glycolide) (PLGA) and Poly(vinyl-alcohol) PVA into the tumor site of mouse models. The charged patch is installed on top of the skin in the mouse models' tumor region, and the controlled selective release of the drug is assayed by biochemical, radiological, and histological experiments on both tumorized models and normal rats' livers. It is found that DLNs synthesized by PLGA show great attraction to PPECs due to their stable negative charges, which would not degrade immediately in blood. The burst and drug release after less than 48h of this synthesized DLNs are 10% and 50%, respectively. These compounds can deliver the loaded-drug into the tumor site with the assistance of PPECs, and the targeted-retarded release will take place. Hence, local therapy can be achieved with much lower drug concentration (conventional chemotherapy [2 mg kg−1] versus DLNs-based chemotherapy [0.75 mg kg−1]) with negligible side effects in non-targeted organs. PPECs have many potential clinical applications for advanced-targeted chemotherapy with the lowest discernible side effects. © 2023 Wiley-VCH GmbH.