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Mycosis Fungoides Two Decades After Exposure to Sulphur Mustard: A Follow-Up of 1100 Victims Publisher Pubmed



Emadi SN1 ; Shiri M1 ; Shiri Z2 ; Emadi SE3 ; Mortazavi H1 ; Nikoo A4 ; Akhavanmoghaddam J5
Authors

Source: Journal of the European Academy of Dermatology and Venereology Published:2017


Abstract

Background: Sulphur mustard (SM) is an alkylating chemical warfare agent which causes acute and chronic injuries to the eyes, skin, lung and respiratory tract. Objective: We aimed to investigate the relationship between SM poisoning and Mycosis fungoides (MF) as a late consequence. Material and Methods: In this retrospective study, the medical files of 1100 Iranian veterans confirmed to have exposure to SM agent during the Iraq–Iran war of the 1980s were reviewed. Results: All 10 cases with MF were confirmed by clinical and histopathological examinations. The mean age of the studied subjects was 43.3 ± 9.8 (years). In comparison to MF incidence rate in Iranian general population (0.39/100 000 person-years), we found an incidence rate of 0.799/100 000 person-years for MF among those who had short-term exposure to SM. The most common sites for SM lesions were flexural and thin skin areas. The main limitation was the retrospective design. Conclusion: This study indicates that the risk of MF in those exposed to SM may increase over time. Therefore, their follow-up is recommended. © 2016 European Academy of Dermatology and Venereology
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