Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Associations Between Dietary Omega-6, Omega-3, and Omega 6 to Omega 3 Ratio Fatty Acids and Hypertension Risk Among Adults: A Prospective Cohort Study Publisher Pubmed



Shakiba E1 ; Pasdar Y1, 2 ; Ebrahimimousavi S3 ; Najafi F1 ; Saber A2 ; Shakiba MH4 ; Bagheri A2
Authors

Source: Clinical Nutrition ESPEN Published:2025


Abstract

Background and aims: Previous studies have yielded mixed results on the connection between dietary omega-3 and omega-6 intakes and the risk of hypertension (HTN) incidents. Therefore, we conducted a study to survey the connection between baseline dietary intake of omega-3, omega-6, and omega-6 to omega 3 (omega-6/3) fatty acids (FA) and the risk of hypertension. Methods: We conducted a prospective cohort study and assessed dietary intake through a 118-item food frequency questionnaire (FFQ). To determine the relationship between dietary omega-3, omega-6, and omega-6/3 ratio intake and the risk of developing hypertension, we applied Cox proportional hazards analysis to determine hazard ratios (HR) and 95 % confidence intervals (CIs). Results: After following 7359 participants who did not have hypertension at the beginning of the study for 6.4 ± 1.33 years, we identified 597 new cases of hypertension (8.11 %). Our analysis, which controlled for all confounders, did not identify any significant link among the highest versus lowest quartile of dietary omega-3 intake (HR: 0.87, 95 % CI: 0.63, 1.18; P trend: 0.34), omega-6 intake (HR: 1.04; 95 % CI: 0.81, 1.34; P trend: 0.82), and omega-6/3 ratio intakes (HR: 1.06, 95 % CI: 0.82, 1.36; P trend: 0.66) and HTN risk. Conclusions: To sum up, our study revealed that dietary omega-3, omega-6, and omega-6/3 ratio were not associated with the hypertension risk. © 2024 European Society for Clinical Nutrition and Metabolism
Related Docs
View other Related Docs
1. The Relationship of Dietary Omega-3 Fatty Acid and Omega-6 to Omega-3 Ratio Intake and Likelihood of Type 2 Diabetes in a Cross-Sectional Study, BMC Endocrine Disorders (2024)
2. Association of Dietary Fats With Ischemic Heart Disease (Ihd): A Case–Control Study, Journal of Health# Population and Nutrition (2024)
3. Adherence to Dietary Approaches to Stop Hypertension Eating Plan in Relation to Gastric Cancer, Nutrition Journal (2020)
Experts (# of related papers)
View all Related Experts
Reza Malekzadeh (5)
Hossein Poustchi (5)
Other Related Docs
4. Relationship Between Nutrients Intake and the Risk of Prostate Cancer: A Case-Control Study in Kermanshah, Iran, Nutrition and Food Science (2018)
5. Dietary Intake of Total, Animal and Plant Proteins and the Risk of Coronary Heart Disease and Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
6. The Association of Dietary Approaches to Stop Hypertension (Dash) Diet With the Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies, Nutrition and Cancer (2020)
7. The Effects of Vitamin D and Omega-3 Co-Supplementation on Lipid Profile in Adults: A Systematic Review and Meta-Analysis, Nutrition and Food Science (2024)
8. The Association Between Dietary Obesity-Prevention Score and Cardiovascular Risk Factors, BMC Nutrition (2025)
9. Adherence to the Dash Diet and Risk of Breast Cancer, Clinical Breast Cancer (2022)
10. Dietary Intakes of Monounsaturated Fatty Acids and Risk of Mortality From All Causes, Cardiovascular Disease and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Ageing Research Reviews (2021)
11. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study, American Journal of Epidemiology (2017)
12. A Posteriori Dietary Patterns and Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis of Observational Studies, Public Health Nutrition (2018)
13. The Relationship Between Dietary Patterns, Dietary Quality Index, and Dietary Inflammatory Index With the Risk of All Types of Cancer: Golestan Cohort Study, Medical Journal of the Islamic Republic of Iran (2021)
14. Impact of 2017 Acc/Aha Guideline on Prevalence, Awareness, Treatment, Control, and Determinants of Hypertension: A Population-Based Cross-Sectional Study in Southwest of Iran, Population Health Metrics (2021)
15. The Application of Six Dietary Scores to a Middle Eastern Population: A Comparative Analysis of Mortality in a Prospective Study, European Journal of Epidemiology (2019)
16. Association Between Adherence to the Dietary Approaches to Stop Hypertension Diet With Food Security and Weight Status in Adult Women, Nutrition and Dietetics (2018)
17. Dietary Protein Sources and All-Cause and Cause-Specific Mortality: The Golestan Cohort Study in Iran, American Journal of Preventive Medicine (2017)
18. Dietary Acid Load and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Observational Studies, Public Health Nutrition (2019)
19. Adherence to the Healthy Eating Index and Alternative Healthy Eating Index Dietary Patterns and Mortality From All Causes, Cardiovascular Disease and Cancer: A Meta-Analysis of Observational Studies, Journal of Human Nutrition and Dietetics (2017)
20. Comparing the Risk of Cardiovascular Diseases and All-Cause Mortality in Four Lifestyles With a Combination of High/Low Physical Activity and Healthy/Unhealthy Diet: A Prospective Cohort Study, International Journal of Behavioral Nutrition and Physical Activity (2022)