A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19

A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19 Publisher

Dehghanbanadaki H^{1, 2} ; Aazami H^{3, 4} ; Shabani M⁵ ; Amighi D⁵ ; Seif F⁶ ; Dehnavi AZ⁵ ; Hajighadery A⁷ ; Nejad MMM⁷ ; Ghafouri M⁵ ; Hajizadeh N⁸ ; Abedin F⁵ ; Hajizadeh Z⁸ ; Heravi M⁹ ; Panahi P¹⁰ Show All Authors

Dehghanbanadaki H^{1, 2}
Aazami H^{3, 4}
Shabani M⁵
Amighi D⁵
Seif F⁶
Dehnavi AZ⁵
Hajighadery A⁷
Nejad MMM⁷
Ghafouri M⁵
Hajizadeh N⁸
Abedin F⁵
Hajizadeh Z⁸
Heravi M⁹
Panahi P¹⁰
Kabir A¹¹

Source: Immunopathologia Persa Published:2022

Abstract

Introduction: Prominent prognostic parameters that reflect the severity of coronavirus disease 2019 (COVID-19) to adopt an appropriate therapeutic approach are not fully identified. This systematic review and meta-analysis aimed to explore the association between lymphocyte variation and disease severity in COVID-19 individuals. Methods: We searched Web of Science, Scopus, PubMed, EMBASE and WHO website to retrieve studies investigating lymphocyte subset counts in non-severe and severe cases of COVID-19. The pooled standardized mean difference (SMD) between two groups and the pooled average count of each lymphocyte subset were assessed by employing a random-effect model. Results: Thirty-nine investigations on 5087 participants, including 3578 non-severe patients and 1509 severe patients, were included. The pooled analysis showed that non-severe patients had higher total T lymphocytes (SMD = 1.01; 95% CI: 0.82, 1.20; I2 = 75.7%), T helper cells (SMD = 1.07; 95% CI: 0.85, 1.28; I2 = 85.4%), T cytotoxic cells (SMD = 1.07; 95% CI: 0.82, 1.32; I2 = 87.1%), B cells (SMD = 0.72; 95% CI: 0.45, 0.98; I2 = 79.7%), and natural killer cells (SMD = 0.65; 95% CI: 0.47, 0.84; I2 = 63.1%) than severe patients and the average count of the corresponding lymphocyte signatures in non-severe patients/severe patients were 878.88/448.40, 493.12/268.96, 311.91/158.91, 177.09/110.37, and 155.02/103.09 cells/μL, respectively. Conclusion: Lymphopenia may be a dilemma in COVID-19 management because over-activation of lymphocytes may lead to cytokine storm or acute respiratory distress syndrome (ARDS). In contrast, lymphopenia may increase SARS-CoV-2 amplification and COVID-19 severity. Therefore, novel therapies targeting lymphocyte proliferation or contraction may counterbalance lymphocyte counts in these patients. © 2022 The Authors.

Related Docs

View other Related Docs

1. Immunophenotyping Characteristics of Covid-19 Patients: Peripheral Blood Cd8+ Hla-Dr+ T Cells As a Biomarker for Mortality Outcome, Journal of Medical Virology (2023)

2. Risk Factors for Adverse Outcomes of Covid-19 Patients: Possible Basis for Diverse Responses to the Novel Coronavirus Sars-Cov-2, Life Sciences (2021)

3. Dynamic Changes of Lymphocyte Subsets in the Course of Covid-19, International Archives of Allergy and Immunology (2021)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (6)

Alireza Abdollahi (2)

Style	Citing Format
MLA	Dehghanbanadaki H, et al.. "A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19." Immunopathologia Persa, vol. 8, no. 2, 2022, pp. -.
APA	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, Hajighadery A, Nejad MMM, Ghafouri M, Hajizadeh N, Abedin F, Hajizadeh Z, Heravi M, Panahi P, Kabir A (2022). A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19. Immunopathologia Persa, 8(2), -.
Chicago	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, Hajighadery A, et al.. "A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19." Immunopathologia Persa 8, no. 2 (2022): -.
Harvard	Dehghanbanadaki H et al. (2022) 'A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19', Immunopathologia Persa, 8(2), pp. -.
Vancouver	Dehghanbanadaki H, Aazami H, Shabani M, Amighi D, Seif F, Dehnavi AZ, et al.. A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19. Immunopathologia Persa. 2022;8(2):-.
BibTex	@article{ author = {Dehghanbanadaki H and Aazami H and Shabani M and Amighi D and Seif F and Dehnavi AZ and Hajighadery A and Nejad MMM and Ghafouri M and Hajizadeh N and Abedin F and Hajizadeh Z and Heravi M and Panahi P and Kabir A}, title = {A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19}, journal = {Immunopathologia Persa}, volume = {8}, number = {2}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Dehghanbanadaki H AU - Aazami H AU - Shabani M AU - Amighi D AU - Seif F AU - Dehnavi AZ AU - Hajighadery A AU - Nejad MMM AU - Ghafouri M AU - Hajizadeh N AU - Abedin F AU - Hajizadeh Z AU - Heravi M AU - Panahi P AU - Kabir A TI - A Systematic Review and Meta-Analysis on the Association Between Lymphocyte Subsets and the Severity of Covid-19 JO - Immunopathologia Persa VL - 8 IS - 2 SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Abstract