Postinjury Treatment With Magnesium Sulfate Attenuates Neuropathic Pains Following Spinal Cord Injury in Male Rats Publisher Pubmed



Farsi L^{1, 2} ; Afshari K² ; Keshavarz M^{2, 3} ; Naghibzadeh M² ; Memari F⁴ ; Norouzijavidan A¹
Source: Behavioural Pharmacology Published:2015

Abstract

Spinal cord injury (SCI) has a number of severe and disabling consequences including chronic pain. Approximately 40% of patients experience neuropathic pain, which appears to be persistent. Previous studies have demonstrated the neuroprotective effects of magnesium sulfate (MgSO 4). We aimed to investigate the effect of MgSO 4 on neuropathic pains following SCI in male rats. Thirty-two adult male rats (weight 300-350 g) were used. After laminectomy, a complete SCI was induced by compression of the spinal cord for 1 min with an aneurysm clip. A single dose of 300 or 600 mg/kg MgSO 4 was injected intraperitoneally. Tail-flick latency and acetone drop test scores were evaluated before surgery and once a week for 4 weeks after surgery. Rats in groups SCI+Mg300 and SCI+Mg600 showed significantly higher mean tail-flick latencies and lower mean scores in the acetone test compared with those in the SCI+veh group 4 weeks after surgery (P<0.05). These findings revealed that systemic single-dose administration of MgSO 4 can attenuate thermal hyperalgesia and cold allodynia induced by SCI in rats. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.