Preparation and Validation of [67Ga]Ga-Phytate Kit and Monte Carlo Dosimetry: An Effort Toward Developing an Impressive Lymphoscintigraphy Tracer Publisher



Bayat Z¹ ; Saeedzadeh E¹ ; Vahidfar N² ; Sadeghi M³ ; Farzenefar S² ; Daha FJ⁴ ; Salehi Y²
Source: Journal of Radioanalytical and Nuclear Chemistry Published:2022

Abstract

Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [67Ga]Ga-phytate, as an long-lived alternative for [99mTc]Tc-radiocolloids was prepared. Standard labeling conditions for [67Ga]Ga-phytate preparation (95–100 °C, 30 min, 0.5 mg phytic acid, aqueous solutions) has been adopted (radiochemical purity: > 98 ± 2% ITLC, specific activity: 0.9–1.1 GBq/mmol). The complex is mainly cleared from the blood pool through the liver by hepatic system (> 90%) and a small percentage (< 7–8%) through the kidneys by renal excretion. Dosimetric simulations showed that the final radiopharmaceutical doses are safe for clinical administrations. © 2022, Akademiai Kiado, Budapest, Hungary.