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An Efficient One-Pot Synthesis of 3-Aryl-5-(Dialkoxymethyl)-1,2,4-Oxadiazoles Under Solvent-Free Conditions Publisher



Adib M1 ; Saeedi S1 ; Soheilizad M1 ; Bayanati M1 ; Tajbakhsh M2 ; Amanlou M3
Authors

Source: Journal of Chemical Research Published:2016


Abstract

An efficient and simple synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with alkyl 2,2-dialkoxyacetates under solvent-free conditions to produce the title compounds in excellent yields. © 2016, Science Reviews 2000 Ltd. All rights reserved.