Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Concept of Immunogenetics Publisher Pubmed



Rajabi F1, 2 ; Jabalameli N1 ; Rezaei N3, 4, 5
Authors

Source: Advances in Experimental Medicine and Biology Published:2022


Abstract

Genetics plays a major role in shaping the immune responses in both physiological and pathological states such as psoriasis, alopecia areata, and other immune-mediated dermatological conditions. The genes encoding the elements of the immune system and its regulators are among the most polymorphous loci in the genome. Subtle variations in these genes can thus alter the balanced defensive responses of the immune system and make an individual liable to diseases and environmental triggers. Immunogenetics deals with finding the precise set of liability genes involved in the pathogenesis of specific complex diseases. In this chapter, we will briefly discuss the basic principles of genetic polymorphisms, the methods used in scanning these polymorphisms, and the strategies employed to find the role of these polymorphisms in complex diseases. © 2022, Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. The Immunogenetics of Alopecia Areata, Advances in Experimental Medicine and Biology (2022)
2. Etiopathogenesis of Psoriasis From Genetic Perspective: An Updated Review, Current Genomics (2022)
3. Investigating the Relationship Between the Vntr Variant of the Interleukin-1 Receptor Antagonist Gene and Coronary In-Stent Restenosis, Molecular Biology Reports (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (6)
Ali Akbar Amirzargar (3)
Other Related Docs
4. Research Techniques Made Simple: Genome-Wide Homozygosity/Autozygosity Mapping Is a Powerful Tool for Identifying Candidate Genes in Autosomal Recessive Genetic Diseases, Journal of Investigative Dermatology (2018)
5. Genetic Variants Within Anril (Antisense Non Coding Rna in the Ink4 Locus) Are Associated With Risk of Psoriasis, International Immunopharmacology (2020)
6. Immunogenetics of Cancer, Cancer Immunology: A Translational Medicine Context# Second Edition (2020)
7. Simmunogenetics of Cancer, Cancer Immunology: A Translational Medicine Context (2015)
8. Association Between Single Nucleotide Polymorphisms of the Interleukin-4 Gene and Atopic Dermatitis, Acta Dermatovenerologica Croatica (2015)
9. Copy Number Variation of Il17ra Gene and Its Association With the Ankylosing Spondylitis Risk in Iranian Patients: A Case-Control Study, BMC Medical Genetics (2020)
10. In Silico Dissection of Mirna Targetome Polymorphisms and Their Role in Regulating Mirna-Mediated Gene Expression in Esophageal Cancer, Cell Biochemistry and Biophysics (2016)
11. Identification of New Tsga10 Transcript Variants in Human Testis With Conserved Regulatory Rna Elements in 5'Untranslated Region and Distinct Expression in Breast Cancer, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (2017)
12. Novel Manifestations of Warburg Micro Syndrome Type 1 Caused by a New Splicing Variant of Rab3gap1: A Case Report, BMC Neurology (2021)
13. Macrophage Migration Inhibitory Factor Polymorphism (Rs755622) in Alopecia Areata: A Possible Role in Disease Prevention, Archives of Dermatological Research (2019)
14. Identification and Prediction of Common Molecular Culprits Between Psoriasis and Melanoma Via Bioinformatical Analysis, Gene Reports (2021)
15. Nlrp3 Gene Polymorphisms in Iranian Patients With Recurrent Aphthous Stomatitis, Journal of Oral Pathology and Medicine (2016)
16. Association of the Genetic Polymorphisms in Inhibiting and Activating Molecules of Immune System With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2021)
17. The Overlap Between Genetic Susceptibility to Covid-19 and Skin Diseases, Immunological Investigations (2022)
18. A Single Nucleotide Polymorphism Within Hox Transcript Antisense Rna (Hotair) Is Associated With Risk of Psoriasis, International Journal of Immunogenetics (2020)
19. A Novel Deletion Variant in Cln3 With Highly Variable Expressivity Is Responsible for Juvenile Neuronal Ceroid Lipofuscinoses, Acta Neurologica Belgica (2021)
20. Association of Il-17A Gene Polymorphism Rs2275913 With Rheumatoid Arthritis Susceptibility in Iranian Patients, Egyptian Journal of Medical Human Genetics (2025)