Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies

Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies Publisher

Mirzaei A¹ ; Jalilian AR¹ ; Shabani G¹ ; Fakhari A² ; Akhlaghi M³ ; Beiki D³

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016

Abstract

In this work development of 68Ga-ethyl cysteinate dimer (68Ga-ECD) a 68Ga tracer for possible cerebral blood flow based on 99mTc ECD homolog is reported. 68Ga-ECD was prepared using generator-based 68GaCl3 and ECD at optimized conditions. Quality control, stability, partition co-efficient and the biodistribution of the tracer (by tissue counting and PET/CT in rats) was studied. Significant metabolism of the lipophilic tracer into water soluble metabolite(s) led to urinary excretion of the tracer, un-comparable to that of homologous 99mTc-compound. Cardiac uptake of the complex suggests formation of a possible lipophil cationic complex and/or metabolite. © 2015, Akademiai Kiado, Budapest, Hungary.

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Style	Citing Format
MLA	Mirzaei A, et al.. "Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies." Journal of Radioanalytical and Nuclear Chemistry, vol. 307, no. 1, 2016, pp. 725-732.
APA	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D (2016). Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies. Journal of Radioanalytical and Nuclear Chemistry, 307(1), 725-732.
Chicago	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D. "Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies." Journal of Radioanalytical and Nuclear Chemistry 307, no. 1 (2016): 725-732.
Harvard	Mirzaei A et al. (2016) 'Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies', Journal of Radioanalytical and Nuclear Chemistry, 307(1), pp. 725-732.
Vancouver	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D. Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies. Journal of Radioanalytical and Nuclear Chemistry. 2016;307(1):725-732.
BibTex	@article{ author = {Mirzaei A and Jalilian AR and Shabani G and Fakhari A and Akhlaghi M and Beiki D}, title = {Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {307}, number = {1}, pages = {725-732}, year = {2016} }
RIS	TY - JOUR AU - Mirzaei A AU - Jalilian AR AU - Shabani G AU - Fakhari A AU - Akhlaghi M AU - Beiki D TI - Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies JO - Journal of Radioanalytical and Nuclear Chemistry VL - 307 IS - 1 SP - 725 EP - 732 PY - 2016 ER -

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