Acute Promyelocytic Leukemia As a Differential Diagnosis of Crimean-Congo Hemorrhagic Fever Publisher



M Beheshti MOHADESE ; S Yazdani SHAGHAYEGH ; M Salehivaziri MOSTAFA ; M Sajadi MARZYIE ; Mh Pouriayevali Mohammad HASSAN
Source: Future Virology Published:2024

Abstract

Aim: This study aimed to investigate acute promyelocytic leukemia (APL) with an abnormal fusion gene in suspected Crimean-Congo hemorrhagic fever (CCHF) cases that were CCHF virus PCR/IgM negative. Materials & methods: A total of 102 serum samples from CCHF suspected cases were included. A TaqMan Real-Time PCR assay was used to detect the APL associated abnormal gene fusion. Results: Totally, the APL was detected in 2 (1.96%) serum samples, both of them were from fetal female cases. No statistically significant association was found between APL and demographic, clinical and laboratory data. Conclusion: Recognizing APL in CCHF-suspected individuals is crucial for accurate differential diagnosis due to shared clinical symptoms and the necessity of its emergency diagnosis, especially in endemic areas. © 2024 Elsevier B.V., All rights reserved.