Efficacy of Ozone Therapy in Dentistry With Approach of Healing, Pain Management, and Therapeutic Outcomes: A Systematic Review of Clinical Trials Publisher Pubmed



Rezaeianjam M¹ ; Khabazian A² ; Khabazian T² ; Ghorbani F³ ; Abbasi T⁴ ; Asghari S⁵ ; Heidari F⁶ ; Shiri A⁷ ; Naderi M⁸
Source: BMC Oral Health Published:2025

Abstract

Ozone therapy has emerged as a promising treatment modality in dentistry due to its antimicrobial and healing properties. This systematic review aimed to evaluate the recent clinical trials on ozone therapy in dentistry and its impact on therapeutic outcomes. A comprehensive literature search was conducted across multiple databases, including Web of Science, PubMed, and Scopus from January 2018 to December 2024, identifying studies that investigated the use of ozone in dental applications. The findings demonstrated that ozone therapy is effective in improving periodontal health, healing soft tissue after dental implant surgery, and reducing postoperative discomfort. The combination of scaling and root planing with gaseous ozone therapy showed superior periodontal response rates. The use of ozone during endodontics procedures resulted in reduced post-treatment pain, while ozonated materials showed promise in the management of dentinal hypersensitivity. However, it is not recommended in restorative dentistry due to potential adverse effects on dentinal bond strength. The findings of this systematic review supported the integration of ozone therapy into dentistry as an adjunctive therapy. More research is needed to elucidate its mechanisms, optimize application techniques, and evaluate long-term outcomes for patient safety and treatment effectiveness. © The Author(s) 2025.