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Morphological Changes Induced by Extremely Low-Frequency Electric Fields Publisher Pubmed



Imani M1 ; Kazemi S2 ; Saviz M1 ; Farahmand L3 ; Sadeghi B2 ; Farajidana R4
Authors

Source: Bioelectromagnetics Published:2019


Abstract

In this paper, morphological effects of electric fields on avian erythrocytes (nucleated red blood cells) have been studied in detail. Morphological changes include rounding and cytoplasm transparency. It has been shown that the effect is non-thermal. Careful imaging and image analyses have been carried out to show that the degree of this effect is frequency-dependent, and has a higher conversion rate at higher temperatures. Furthermore, to better understand the mechanisms behind the morphological changes, we investigated the dedifferentiation hypothesis and performed a series of tests on avian erythrocytes including fluorescence spectroscopy for hemoglobin, and tests on human umbilical cord blood, mesenchymal stem cells, and bone marrow mesenchymal stem cells including flow-cytometry analysis for expression of certain markers and calcium staining. Bioelectromagnetics. 2019;40:375–390. © 2019 Bioelectromagnetics Society. © 2019 Bioelectromagnetics Society