The Role of Epigenetic Regulation in Senescence and Its Implication in Aging Publisher



Shah I ; Hussain Y ; Ahmad S ; Khan F ; Hodjat M
Source: Cellular Aging and Consequences in Humans: Nutritional and Clinical Studies Published:2025

Abstract

Aging is a complicated deteriorative process affecting structure and physiological function of different organs. Senescence as the state of permanent cease of cell proliferation is the key actor associated with the aging process. Finding the precise mechanisms of this phenomenon is crucial in the search for therapeutic interventions of aging and age-related disease. Epigenetic changes have been widely recognized in recent years as the mediators of aging that promote alteration in the expression of genes underlying age-related disorders. Changes of global DNA methylation and site-specific methylation of particular genes were reported in cells undergoing senescence as well as aging organisms. Histone modification such as methylation, acetylation, and ubiquitination also varies during aging and the manipulation of histone modifying enzyme affecting the longevity. Nutrients and nutraceuticals play an important role in halting the aging process and age-related disease. A healthy diet and lifestyle can help to slow down epigenetic age acceleration through affecting the epigenetic modifier enzymes or availability of enzymes substrates. Here, we will introduce the molecular mechanisms associated with senescence and aging with particular focus on the role of epigenetic regulation. Also, the effect of several dietary components in reprogramming age-related epigenetic changes and rejuvenation will be discussed. © 2026 Taylor & Francis Group, LLC.