Determination and Comparison of the Effect of Ibuprofen and Acetaminophen on Postpartum Hypertension in Pregnant Women With a History of Preeclampsia Publisher



Mauwloudi A¹ ; Eslamian L² ; Marsousi V¹ ; Jamal A² ; Noorzadeh M³ ; Naemi M² ; Norouzi AR⁴ ; Mesbah N²
Source: Journal of Obstetrics# Gynecology and Cancer Research Published:2024

Abstract

Background & Objective: The aim of this study was to determine which of the two drugs of ibuprofen, as a common non-steroidal anti-inflammatory drugs (NSAID), and acetaminophen would have the least effect on postpartum hypertension in patients with preeclampsia. Materials & Methods: Clinicodemographic data including age, gestational age at delivery, body mass index, parity, and route of delivery, were collected through interviews with patients and reviewing patient records. In this double-blind clinical trial, among 84 patients included in the study, 42 patients were randomly assigned to the acetaminophen (650 mg every 6 to 24 hours) and 42 patients into the ibuprofen (600 mg every 6 to 24 hours) group. Results: The two groups were not significantly different in terms of mean age (P = 0.322), body mass index (P = 0.950), route of delivery (P = 0.657), parity (P = 0.818), and mean systolic (p = 0.530) and diastolic blood pressure (P = 0.691). Following the intervention, the duration of blood pressure control (P = 0.182), mean systolic blood pressure (P = 0.371), and mean diastolic blood pressure (P = 0.13) were not significantly different in the acetaminophen and ibuprofen groups. There was no significant difference between the two groups in terms of the number of patients and the dosage of opioids used. Conclusion: The results revealed that in patients with preeclampsia, acetaminophen and ibuprofen to control postpartum pain have a similar impact on blood pressure. © 2024, Farname Inc. All rights reserved.