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The Effect of Lipopolysaccharide on the Expression Level of Immunomodulatory and Immunostimulatory Factors of Human Amniotic Epithelial Cells Publisher Pubmed



Taheri RA1 ; Motedayyen H2 ; Ghotloo S3 ; Masjedi M2 ; Mosaffa N4 ; Mirshafiey A3 ; Saffari M3, 5
Authors

Source: BMC Research Notes Published:2018


Abstract

Objective: Human amniotic epithelial cells (hAECs) are a novel source of stem cells and have immunomodulatory effects on both the innate and adoptive immune system. hAECs can differentiate into multiple cell lineages that make them a suitable cell source for regenerative medicine. These cells express multiple toll-like receptors (TLRs) and respond to various TLR ligands. This study aimed to evaluate the effect of lipopolysaccharide (LPS), a TLR4 ligand, on the level of immunomodulatory and immunostimulatory factors of hAECs. Results: Our results indicated that LPS had the ability to up-regulate the expression of prostaglandin E2 synthase and transforming growth factor-beta1 in hAECs. However, there was no change in the level of interleukin-1beta, interleukin-6 and interleukin-10 in hAECs when were stimulated with LPS. In addition, we observed tumor necrosis factor-alpha was only expressed at very low level in some of hAECs samples which its expression was independent of the effects of LPS. © 2018 The Author(s).
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