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Meropenem/Colistin Versus Meropenem/Ampicillin-Sulbactam in the Treatment of Carbapenem-Resistant Pneumonia Publisher Pubmed



Khalili H1 ; Shojaei L2 ; Mohammadi M3 ; Beigmohammadi MT3 ; Abdollahi A4 ; Doomanlou M5
Authors

Source: Journal of Comparative Effectiveness Research Published:2018


Abstract

Aim: Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A. baumannii. Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A. baumannii. Method: 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A. baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days. Clinical and microbiological responses and 28-day mortality were considered as outcomes. Results: Clinical response (75 vs 69.6%; p = 0.75) and microbial eradication (87.50 vs 91.3%; p = 0.59) were comparable between meropenem/colistin and meropenem/ampicillin-sulbactam groups, respectively. Conclusion: In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups. © 2018 Future Medicine Ltd.
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