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The Helicobacter Pylori Genome Project: Insights Into H. Pylori Population Structure From Analysis of a Worldwide Collection of Complete Genomes Publisher Pubmed



Thorell K1 ; Munozramirez ZY2 ; Wang D3, 4 ; Sandovalmotta S5, 6, 7 ; Boscolo Agostini R8 ; Ghirotto S8 ; Torres RC9 ; Romerogallo J10 ; Krishna U10 ; Piazuelo MB10 ; Raaf N11 ; Bentolila F12 ; Aftab H13 ; Akada J14 Show All Authors
Authors
  1. Thorell K1
  2. Munozramirez ZY2
  3. Wang D3, 4
  4. Sandovalmotta S5, 6, 7
  5. Boscolo Agostini R8
  6. Ghirotto S8
  7. Torres RC9
  8. Romerogallo J10
  9. Krishna U10
  10. Piazuelo MB10
  11. Raaf N11
  12. Bentolila F12
  13. Aftab H13
  14. Akada J14
  15. Matsumoto T14
  16. Haesebrouck F15
  17. Colanzi RP16
  18. Bartelli TF17
  19. Nunes DN17
  20. Pelosof A17
  21. Sztokfisz CZ17
  22. Diasneto E17
  23. Assumpcao PP18
  24. Tishkov I19
  25. Mabeku LBK20
  26. Goodman KJ21
  27. Geary J21
  28. Cromarty TJ21
  29. Price NL21
  30. Quilty D22
  31. Corvalan AH23
  32. Serrano CA24
  33. Gonzalez R25
  34. Riquelme A25
  35. Garciacancino A26
  36. Parrasepulveda C26
  37. Bernal G27
  38. Castillo F28
  39. Goldstein AM4
  40. Hu N4
  41. Taylor PR4
  42. Bravo MM29
  43. Pazos A30
  44. Bravo LE31
  45. Wilson KT10
  46. Fox JG32
  47. Ramirezmayorga V33
  48. Molinacastro S33
  49. Duranbermudez S34
  50. Camposnunez C35
  51. Chavescervantes M35
  52. Tshibangukabamba E36, 37
  53. Tumba GD37
  54. Tshimpiwola A38
  55. De Jesus Ngomakisoko P38
  56. Ngoyi DM38, 39
  57. Cruz M40
  58. Hosking C40
  59. Abreu JJ41
  60. Varon C42
  61. Benejat L42
  62. Secka O43
  63. Link A44
  64. Malfertheiner P44
  65. Adinortey MB45
  66. Bockarie AS46
  67. Adinortey CA47
  68. Ofori EG48
  69. Sgouras DN49
  70. Martinezgonzalez B49
  71. Michopoulos S50
  72. Georgopoulos S51
  73. Hernandez E52
  74. Tacatic BV53
  75. Aguilar M54
  76. Dominguez RL55
  77. Morgan DR56
  78. Harardottir H57
  79. Gunnarsdottir AI57
  80. Gujonsson H57
  81. Jonasson JG57, 58
  82. Bjornsson ES57, 58
  83. Ballal M59
  84. Shetty V59, 60
  85. Miftahussurur M61
  86. Sugihartono T61
  87. Alfaray RI61
  88. Waskito LA61
  89. Fauzia KA61
  90. Syam AF62
  91. Maulahela H62
  92. Malekzadeh R63
  93. Sotoudeh M63
  94. Peretz A64, 65
  95. Azrad M64, 65
  96. On A65, 66
  97. De Re V67
  98. Zanussi S67
  99. Cannizzaro R68
  100. Canzonieri V69
  101. Shimura T70
  102. Tokunaga K71
  103. Osaki T71
  104. Kamiya S71
  105. Jadallah K72
  106. Matalka I72
  107. Igissinov N73
  108. Moldobaeva MS74
  109. Rakhat A74
  110. Choi IJ75
  111. Kim JG76
  112. Kim N77
  113. Song M4
  114. Leja M78, 79, 80
  115. Vangravs R78
  116. Skenders G78, 80
  117. Rudzite D80
  118. Rudule A78
  119. Vanags A79
  120. Kikuste I78
  121. Kupcinskas J81
  122. Skieceviciene J81
  123. Jonaitis L81
  124. Kiudelis G81
  125. Jonaitis P81
  126. Kiudelis V81
  127. Varkalaite G81
  128. Vadivelu J82, 83
  129. Loke MF82
  130. Vellasamy KM82
  131. Herreragoepfert R84
  132. Alonsolarraga JO85
  133. Yee TT86
  134. Htet K86
  135. Matsuhisa T87
  136. Shrestha PK88
  137. Ansari S89
  138. Abiodun O90
  139. Jemilohun C91
  140. Akande KO92
  141. Oluabiodun O93
  142. Magaji FA94
  143. Omotoso A95
  144. Osuagwu CC96
  145. Okonkwo U95
  146. Owoseni OO97
  147. Castaneda C98
  148. Castillo M99
  149. Velapatino B100
  150. Gilman RH101
  151. Krzyzek P102
  152. Gosciniak G102
  153. Pawelka D103
  154. Koronaglowniak I104
  155. Cichozlach H105
  156. Oleastro M106
  157. Figueiredo C107, 108, 109
  158. Machado JC107, 108, 109
  159. Ferreira RM107, 108
  160. Bordin DS110, 111, 112
  161. Livzan MA113
  162. Tsukanov VV114
  163. Tan P115, 116, 117
  164. Yeoh KG118, 119
  165. Zhu F118
  166. Ally R120, 121
  167. Haas R122
  168. Montes M123
  169. Fernandezreyes M123
  170. Tamayo E123
  171. Lizasoain J123
  172. Bujanda L124
  173. Lario S125, 126
  174. Ramirezlazaro MJ125, 126
  175. Calvet X125, 126
  176. Brunetmas E125, 126
  177. Domperarnal MJ127, 128
  178. Garciamateo S127, 128
  179. Abadbaroja D129
  180. Delgadoguillena P130
  181. Moreira L131
  182. Botargues J132
  183. Perezmartinez I133, 134
  184. Barreiroalonso E133, 135, 136
  185. Flores V137
  186. Gisbert JP138, 139
  187. Muro EA140
  188. Linares P141
  189. Martin V142
  190. Alcoba L141
  191. Fleitaskanonnikoff T143
  192. Altayeb HN144, 145
  193. Engstrand L146
  194. Enroth H147
  195. Keller PM148, 149
  196. Wagner K150
  197. Pohl D151
  198. Lee YC152
  199. Liou JM152
  200. Wu MS152
  201. Kocazeybek B153
  202. Saribas S153
  203. Tasci I154
  204. Demiryas S154
  205. Kepil N155
  206. Quiel L156
  207. Villagra M157
  208. Norton M158
  209. Johnson D158
  210. Huang RJ159
  211. Hwang JH159
  212. Szymczak W160
  213. Rajagopalan S160
  214. Asare E160
  215. Jacobs Jr WR160
  216. In H160, 161
  217. Bollag R162
  218. Lopez A162
  219. Kruse EJ163
  220. White J163
  221. Graham DY164
  222. Lane C165
  223. Gao Y165
  224. Fields PI165
  225. Gold BD166
  226. Cruzcorrea M167, 168
  227. Gonzalezpons M167
  228. Rodriguez LM169
  229. Tuan VP170
  230. Dung HDQ170
  231. Binh TT170
  232. Trang TTH171
  233. Van Khien V171
  234. Chen X172
  235. Raley C173
  236. Kessing B173
  237. Zhao Y172
  238. Tran B173
  239. Gutierrezescobar AJ4
  240. Wan Y3
  241. Hicks B3
  242. Zhu B3
  243. Yu K4
  244. Zhu B3
  245. Yeager M3
  246. Hutchinson A3
  247. Teshome K3
  248. Jones K3
  249. Luo W3
  250. Jehanne Q42
  251. Katsura Y174
  252. Gonzalezhormazabal P175
  253. Didelot X176
  254. Sheppard S177
  255. Tarazonasantos E178
  256. Marinoramirez L179
  257. Loh JT10
  258. Backert S180
  259. Naumann M181
  260. Abnet CC4
  261. Smet A182
  262. Berg DE183
  263. Chineroms A184, 185
  264. Comas I185, 186
  265. Martinezmartinez FJ186
  266. Zamudio R178, 187
  267. Lehours P42
  268. Megraud F42
  269. Yahara K188
  270. Blaser MJ189
  271. Vincze T190
  272. Morgan RD190
  273. Roberts RJ190
  274. Chanock SJ4
  275. Dekker JP191
  276. Torres J192
  277. Cover TL10, 193
  278. Noureen M194
  279. Fischer W122
  280. Vale FF195, 196
  281. Cherry JL197, 198
  282. Osada N199
  283. Fukuyo M200
  284. Arita M201
  285. Yamaoka Y14, 164
  286. Kobayashi I202
  287. Uchiyama I203
  288. Falush D9
  289. Camargo MC4
  290. Rabkin CS4

Source: Nature Communications Published:2023


Abstract

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics. © 2023, The Author(s).
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