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Fucoidan and Its Derivatives: From Extraction to Cutting-Edge Biomedical Applications Publisher Pubmed



Abbas MF1 ; Karim DK1 ; Kareem HR1 ; Kamil MM2 ; Almusawi MH1 ; Asker MH3 ; Ghanami M4 ; Shahriarikhalaji M4 ; Sattar M5 ; Mirhaj M6 ; Sharifianjazi F7, 8 ; Tavamaishvili K9 ; Mohabbatkhah M10 ; Soheily A11 Show All Authors
Authors
  1. Abbas MF1
  2. Karim DK1
  3. Kareem HR1
  4. Kamil MM2
  5. Almusawi MH1
  6. Asker MH3
  7. Ghanami M4
  8. Shahriarikhalaji M4
  9. Sattar M5
  10. Mirhaj M6
  11. Sharifianjazi F7, 8
  12. Tavamaishvili K9
  13. Mohabbatkhah M10
  14. Soheily A11
  15. Noory P12
  16. Tavakoli M6

Source: Carbohydrate Polymers Published:2025


Abstract

Fucoidan, a sulfated polymeric carbohydrate isolated from various marine brown algae, has attracted the interest of biomedical scientists because of its unique structural features and extensive spectrum of biological activity. This review encompasses a comprehensive insight into fucoidan's extraction procedures, cross-linking strategies, chemical modifications, and biomedical applications. Advanced extraction methods, such as microwave-assisted and enzyme-assisted extraction, are emphasized to get high-quality fucoidan that has augmented bioactivity. Moreover, the production and role of fucoidan-based materials in drug delivery systems are investigated, with a focus on their potential for targeted therapies. The study also explores the strategies to improve fucoidan's bioavailability and mechanical properties via structural modifications, such as Sulfation, desulfation, methylation, benzoylation, sulfation, amination, acetylation and phosphorylation, and cross-linking with other polymers to form films, hydrogels, and nanocomposites. In addition, fucoidan's applications in drug delivery systems, tissue engineering, microneedles, and 3D bioprinting are discussed. By summarizing current research findings, this study seeks to comprehend the mechanisms underpinning fucoidan's therapeutic efficacy and its potential to develop robust biomaterials. © 2025 Elsevier Ltd
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