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Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review Publisher Pubmed



Sadatshirazi MS1 ; Sadeghiadl M1 ; Akbarabadi A1 ; Ashabi G2 ; Mokri A1, 3 ; Zarrindast MR1, 4, 5, 6
Authors

Source: CNS and Neurological Disorders - Drug Targets Published:2023


Abstract

Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addic-tion. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is cor-related with neurochemical and neurostructural changes in the brain. The current paper reviews the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nic-otine, alcohol, and cannabis) before gestation in animal models. © 2023 Bentham Science Publishers.
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